SMI-16a
- CAS NO.：587852-28-6
- Empirical Formula: C13H13NO3S
- Molecular Weight: 263.31
- MDL number: MFCD31382191
- Update Date: 2024-07-02 08:55:14
What is SMI-16a?
Description
SMI-16a is a Pim-1 kinase inhibitor (IC50 = 63 nM). It is selective for Pim-1 over a panel of 60 kinases. SMI-16a (5 μM) inhibits phosphorylation of the Pim-1 target protein Bad in DU145-Pim cells and inhibits the growth of PC3, DU145, LNCaP, K562, and MV4-11 cancer cells. It induces apoptosis and cell cycle arrest at the G1 phase in DU145 cells.
Properties of SMI-16a
| Melting point: | 186.3-188.4 °C |
| Density | 1.303±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Ethanol:3.0(Max Conc. mg/mL);11.39(Max Conc. mM) |
| form | A solid |
| pka | 7.27±0.20(Predicted) |
| color | Light yellow to yellow |
Safety information for SMI-16a
Computed Descriptors for SMI-16a
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