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HomeProduct name listSELEXIPAG interMediate

SELEXIPAG interMediate

  • CAS NO.:475086-75-0
  • Empirical Formula: C23H27N3O
  • Molecular Weight: 361.48
  • MDL number: MFCD28411750
  • EINECS: 813-799-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-03-22 21:24:34
SELEXIPAG interMediate Structural

What is SELEXIPAG interMediate?

The Uses of SELEXIPAG interMediate

4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-butanol is a diphenylpyrazine derivative which belongs to a class of prostacyclin receptor agonists. It is an impurity of Selexipag (S253150) that is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans.

What are the applications of Application

Selexipag interMediate is a synthetic organic compound that is used as an intermediate in the synthesis of oxychloride. It is an oxychloride with a nucleophilic substitution reaction. The reaction proceeds selectively at the phosphorus atom and gives high yield. The reactivity of 4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butan-1-ol is enhanced by the use of n butanol, which also acts as a solvent for the reaction. The product can be purified by filtration or recrystallization from hexane with piperazine as a reagent.

Properties of SELEXIPAG interMediate

Melting point: 68 - 71°C
Boiling point: 514.4±50.0 °C(Predicted)
Density  1.112±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform (Slightly), DMSO (Slightly)
form  Solid
pka 15.05±0.10(Predicted)
color  Pale Yellow to Light Yellow

Safety information for SELEXIPAG interMediate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for SELEXIPAG interMediate

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