Saxagliptin hydrochloride
- CAS NO.：709031-78-7
- Empirical Formula: C18H25N3O2.HCl
- Molecular Weight: 351.88
- MDL number: MFCD22572334
- EINECS: 696-124-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is Saxagliptin hydrochloride?
Description
Saxagliptin (709031-78-7) is a clinically useful DPPIV inhibitor for the treatment of diabetes.1 ?Human DPP-IV Ki = 0.6 nM.2
The Uses of Saxagliptin hydrochloride
Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once daily dosing.
storage
Store at -20°C
References
Tahrani et al. (2009) Saxagliptin: a new DPP-4 inhibitor for the treatment of type 2 diabetes mellitus; Adv. Ther. 26 249 Augeri et al. (2005) Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes; J. Med. Chem. 48 5025
Properties of Saxagliptin hydrochloride
| Melting point: | >219°C |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (20 mg/ml) |
| form | solid |
| color | White |
| Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Safety information for Saxagliptin hydrochloride
Computed Descriptors for Saxagliptin hydrochloride
| InChIKey | TUAZNHHHYVBVBR-PMEPUXBANA-N |
| SMILES | [C@@H](C12CC3CC(CC(C3)(O)C1)C2)(N)C(N1[C@@H](C[C@@H]2C[C@H]12)C#N)=O.Cl |&1:0,15,17,19,r| |
Saxagliptin hydrochloride manufacturer
Morepen Laboratories Ltd
1Y
Phone:+91-9818305894
Whatsapp: +91 9818305894
product: Saxagliptin hydrochloride 99%
Sibram Pharmaceutical
1Y
Phone:+91-8655777550
Whatsapp: +91-8655777550
product: Saxagliptin hydrochloride 709031-78-7 99%
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)
Maharashtra
product: Saxagliptin hydrochloride
Bazayan & Co.
Maharashtra
Phone:91-9833030098
Whatsapp: 91-9833030098
product: Saxagliptin hydrochloride
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