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HomeProduct name listSacubitril Impurity 7

Sacubitril Impurity 7

Sacubitril Impurity 7 Structural

What is Sacubitril Impurity 7?

The Uses of Sacubitril Impurity 7

Desethyl Sacubitril is an impurity in the synthesis of Sacubitril (S080895), an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Properties of Sacubitril Impurity 7

Boiling point: 705.4±60.0 °C(Predicted)
Density  1?+-.0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
solubility  DMF:30.0(Max Conc. mg/mL);78.24(Max Conc. mM)
DMSO:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.3(Max Conc. mM)
form  A crystalline solid
pka 4.59±0.23(Predicted)
color  White to off-white

Safety information for Sacubitril Impurity 7

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Sacubitril Impurity 7

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