Sacubitril Impurity 7

CAS NO.：149709-44-4
Empirical Formula: C22H25NO5
Molecular Weight: 383.44
MDL number: MFCD00921225
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-14 20:10:21

What is Sacubitril Impurity 7?

The Uses of Sacubitril Impurity 7

Desethyl Sacubitril is an impurity in the synthesis of Sacubitril (S080895), an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Properties of Sacubitril Impurity 7

Boiling point:	705.4±60.0 °C(Predicted)
Density	1?+-.0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMF:30.0(Max Conc. mg/mL);78.24(Max Conc. mM) DMSO:77.0(Max Conc. mg/mL);200.81(Max Conc. mM) Ethanol:77.0(Max Conc. mg/mL);200.81(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.3(Max Conc. mM)
form	A crystalline solid
pka	4.59±0.23(Predicted)
color	White to off-white

Safety information for Sacubitril Impurity 7

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.