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HomeProduct name list(S)-N-Fmoc-2-(2'-propylenyl)alanine

(S)-N-Fmoc-2-(2'-propylenyl)alanine

Synonym(s):(S)-N-Fmoc-α-2-n-propenylalanine;Fmoc-(S)-2-(2-propenyl)alanine;Fmoc-(S)-2-amino-2-methyl-4-pentenoic acid

(S)-N-Fmoc-2-(2'-propylenyl)alanine Structural

What is (S)-N-Fmoc-2-(2'-propylenyl)alanine?

The Uses of (S)-N-Fmoc-2-(2'-propylenyl)alanine

Olefinic alpha-methyl amino acid for peptide stapling. Upon incorporation of this amino acid into a peptide, along with another of the same or derivative with a different length of the olefinic side chain, the two can be ′stapled′ via a ring closing metathesis reaction with Grubb′s catalyst (product # 579726). The resulting stapled peptide macrocycle has been shown to stabilize the alpha-helical structure of peptides, which can lead to favorable biological characteristics such as increased proteolytic stability and cellular uptake.

Properties of (S)-N-Fmoc-2-(2'-propylenyl)alanine

Boiling point: 564.3±45.0 °C(Predicted)
Density  1.224
storage temp.  Inert atmosphere,Store in freezer, under -20°C
form  liquid
pka 3.81±0.11(Predicted)
color  pale yellow

Safety information for (S)-N-Fmoc-2-(2'-propylenyl)alanine

Signal word Warning
Pictogram(s)
ghs
Environment
GHS09
GHS Hazard Statements H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes P273:Avoid release to the environment.

Computed Descriptors for (S)-N-Fmoc-2-(2'-propylenyl)alanine

InChIKey FNCSRFHDUZYOCR-NRFANRHFSA-N

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