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HomeProduct name list(S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL

(S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL

Synonym(s):(S)-(−)-1-(1-Naphthyl)ethanol

  • CAS NO.:15914-84-8
  • Empirical Formula: C12H12O
  • Molecular Weight: 172.22
  • MDL number: MFCD00077831
  • EINECS: 1592732-453-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-04-23 13:52:06
(S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL Structural

What is (S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL?

Chemical properties

White fine crystalline powder

The Uses of (S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL

(S)?-?1-?(Naphthalen-?1-?yl)?ethanol is a building block used in the synthesis of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy.

Purification Methods

Purify the alcohol by recrystallisation from Et2O/pet ether, Et2O, hexane [Balfe et al. J Chem Soc 797 1946, IR, NMR: Theisen & Heathcock J Org Chem 53 2374 1988, see also Fredga et al. Acta Chem Scand 11 1609 1957]. The RS-alcohol [57605-95-5] has m 63-65o, 65-66o from hexane. [Beilstein 6 III 3034, 6 IV 4346.]

Properties of (S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL

Melting point: 47-49 °C(lit.)
Boiling point: 165°C/11mmHg(lit.)
alpha  -77 º (C=1 IN MEOH)
Density  1.113±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
form  Powder
pka 14.29±0.20(Predicted)
color  Yellow
optical activity [α]20/D 77°, c = 1 in methanol
BRN  2045009
InChI InChI=1/C12H12O/c1-9(13)11-8-4-6-10-5-2-3-7-12(10)11/h2-9,13H,1H3/t9-/s3
CAS DataBase Reference 15914-84-8(CAS DataBase Reference)

Safety information for (S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for (S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL

InChIKey CDRQOYRPWJULJN-DJEYLCQNNA-N
SMILES C12C=CC=CC=1C=CC=C2[C@@H](O)C |&1:10,r|

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