(S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL
Synonym(s):(S)-(−)-1-(1-Naphthyl)ethanol
- CAS NO.：15914-84-8
- Empirical Formula: C12H12O
- Molecular Weight: 172.22
- MDL number: MFCD00077831
- EINECS: 1592732-453-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is (S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL?
Chemical properties
White fine crystalline powder
The Uses of (S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL
(S)?-?1-?(Naphthalen-?1-?yl)?ethanol is a building block used in the synthesis of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy.
Purification Methods
Purify the alcohol by recrystallisation from Et2O/pet ether, Et2O, hexane [Balfe et al. J Chem Soc 797 1946, IR, NMR: Theisen & Heathcock J Org Chem 53 2374 1988, see also Fredga et al. Acta Chem Scand 11 1609 1957]. The RS-alcohol [57605-95-5] has m 63-65o, 65-66o from hexane. [Beilstein 6 III 3034, 6 IV 4346.]
Properties of (S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL
| Melting point: | 47-49 °C(lit.) |
| Boiling point: | 165°C/11mmHg(lit.) |
| alpha | -77 º (C=1 IN MEOH) |
| Density | 1.113±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | Powder |
| pka | 14.29±0.20(Predicted) |
| color | Yellow |
| optical activity | [α]20/D 77°, c = 1 in methanol |
| BRN | 2045009 |
| InChI | InChI=1/C12H12O/c1-9(13)11-8-4-6-10-5-2-3-7-12(10)11/h2-9,13H,1H3/t9-/s3 |
| CAS DataBase Reference | 15914-84-8(CAS DataBase Reference) |
Safety information for (S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (S)-(-)-ALPHA-METHYL-1-NAPHTHALENEMETHANOL
| InChIKey | CDRQOYRPWJULJN-DJEYLCQNNA-N |
| SMILES | C12C=CC=CC=1C=CC=C2[C@@H](O)C |&1:10,r| |
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