(S)-4-Hydroxy-2-pyrrolidinone

Synonym(s):(S)-β-Hydroxy-γ-butyrolactam

CAS NO.：68108-18-9
Empirical Formula: C4H7NO2
Molecular Weight: 101.1
MDL number: MFCD00273370
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-08 14:48:35

(S)-4-Hydroxy-2-pyrrolidinone Structural

What is (S)-4-Hydroxy-2-pyrrolidinone?

Chemical properties

White crystal

The Uses of (S)-4-Hydroxy-2-pyrrolidinone

The (S)-enantiomer intermediate in the preparation of Oxiracetam

The Uses of (S)-4-Hydroxy-2-pyrrolidinone

(S)-(?)-4-Hydroxy-2-pyrrolidinone can be used as a starting material in the preparation of:

Biologically significant pyrrolo[1,2:1′,2′]azepino[5,6-b]indole derivatives.
Substituted azepanes by reacting with various aldehydes via photochemical [5+2] cycloaddition.

General Description

4-Hydroxy-2-pyrrolidinone is an important building block found in many bioactive compounds like streptopyrrolidine. It can be used as an intermediate in the synthesis of various γ-amino acids (GABA) and substituted 2-pyrrolidinones like cynometrine and cynodine.

Properties of (S)-4-Hydroxy-2-pyrrolidinone

Melting point:	156-159 °C (lit.)
Boiling point:	363.6±35.0 °C(Predicted)
alpha	-41 º (c=% in ethanol)
Density	1.292±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Water Solubility	Slightly soluble in water
form	Solid
pka	13.62±0.20(Predicted)
color	White to off-white
optical activity	[α]23/D 43°, c = 1 in ethanol
BRN	1524192
CAS DataBase Reference	68108-18-9(CAS DataBase Reference)

Safety information for (S)-4-Hydroxy-2-pyrrolidinone

Signal word	Warning
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.