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HomeProduct name list(S)-3,4-DCPG

(S)-3,4-DCPG

(S)-3,4-DCPG Structural

What is (S)-3,4-DCPG?

The Uses of (S)-3,4-DCPG

(S)-3,4-DCPG is a potent and selective mGluR-8a agonist.

What are the applications of Application

(S)-3,4-DCPG is a potent and selective mGluR-8a agonist

Biological Activity

Potent, selective mGlu 8a agonist (EC 50 = 31 nM). Displays > 100-fold selectivity over mGlu 1-7 and displays little or no activity at NMDA and kainate receptors. Increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo . Also potent anticonvulsant in mice in vivo .

storage

Desiccate at RT

Properties of (S)-3,4-DCPG

Boiling point: 531.0±50.0 °C(Predicted)
Density  1.634±0.06 g/cm3(Predicted)
storage temp.  Desiccate at RT
solubility  DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 10 mg/ml
pka 1.59±0.10(Predicted)
form  Powder
color  White to off-white
Water Solubility  Soluble to 100 mM in water
InChI InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1

Safety information for (S)-3,4-DCPG

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H312:Acute toxicity,dermal
H332:Acute toxicity,inhalation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P330:Rinse mouth.
P363:Wash contaminated clothing before reuse.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P501:Dispose of contents/container to..…

Computed Descriptors for (S)-3,4-DCPG

InChIKey IJVMOGKBEVRBPP-ZETCQYMHSA-N
SMILES C1(C(O)=O)=CC=C([C@H](N)C(O)=O)C=C1C(O)=O

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