(S)-2-AMINOHEX-5-YNOIC ACID
- CAS NO.:98891-36-2
- Empirical Formula: C6H9NO2
- Molecular Weight: 127.14
- MDL number: MFCD11052896
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 20:41:25
What is (S)-2-AMINOHEX-5-YNOIC ACID?
The Uses of (S)-2-AMINOHEX-5-YNOIC ACID
L-Homopropargyl glycine is a reactive methionine analog that contains an alkyne moiety. It is readily inserted into newly-synthesized proteins in place of methionine. L-Homopropargyl glycine can then be labeled or captured through click chemistry. This approach represents a fast, sensitive, and non-radioactive alternative to [35S]-methionine for the detection of nascent protein synthesis.
The Uses of (S)-2-AMINOHEX-5-YNOIC ACID
L-Homopropargylglycine (HPG) is an amino acid analog of methionine that contains a very small modification, specifically an alkyne moiety. This compound can be fed to cultured cells and incorporated into proteins during active protein synthesis. Detection utilizes the chemoselective ligation or “click” reaction between an azide and an alkyne or cyclooctyne. For example the alkyne-modified protein can be detected with either fluorescent azide or biotin azide. Detection sensitivity with these reagents in 1-D gels and Western blots is in the low femtomole range and compatible with downstream LC-MS/MS and MALDI-MS analysis.
What are the applications of Application
L-homopropargylglycine is a reactive methionine analog
Properties of (S)-2-AMINOHEX-5-YNOIC ACID
Melting point: | 162°C |
Boiling point: | 260.5±35.0 °C(Predicted) |
Density | 1.155±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Aqueous Acid (Sparingly), Methanol (Slightly), Water (Slightly) |
form | powder or crystals |
pka | 2.21±0.10(Predicted) |
color | White to Off-White |
Stability: | Hygroscopic |
CAS DataBase Reference | 98891-36-2 |
Safety information for (S)-2-AMINOHEX-5-YNOIC ACID
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 |
GHS Hazard Statements |
H242:Self-reactive substances and mixtures; and Organic peroxides |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P234:Keep only in original container. P235:Keep cool. P240:Ground/bond container and receiving equipment. P370+P378:In case of fire: Use … for extinction. P403:Store in a well-ventilated place. |
Computed Descriptors for (S)-2-AMINOHEX-5-YNOIC ACID
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