(S)-(+)-1-Methoxy-2-propanol

Synonym(s):(S)-(+)-Propylene glycol 1-methyl ether

CAS NO.：26550-55-0
Empirical Formula: C4H10O2
Molecular Weight: 90.12
MDL number: MFCD01632588
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:36

What is (S)-(+)-1-Methoxy-2-propanol?

Chemical properties

Colorless to light yellow liqui

The Uses of (S)-(+)-1-Methoxy-2-propanol

(S)-(+)-1-Methoxy-2-propanol can be used as a reactant to prepare:

(S)-1-methoxypropan-2-yl 4-methylbenzenesulfonate by reacting with tosyl chloride in the presence of pyridine.
Thiazolopyridine urea derivatives.
Quinazoline derivatives as potential inhibitors of EGFR/HER-2 tyrosine kinases.

Purification Methods

Wash the ethers with aqueous NaHCO3 in the presence of solid NaCl, dry them with MgSO4 and fractionally distil them. The RS-acetate [108-65-6] M 132.2 has b 145-146o/atm. The R(+) and S(-) enantiomers have [] D ±20.5o (c 10, H2O). [Beilstein 1 II 536, 1 III 2146, 1 IV 2471.]

Properties of (S)-(+)-1-Methoxy-2-propanol

Melting point:	-84.2°C (estimate)
Boiling point:	118-119 °C
alpha	20 º (c=10, CHCl3)
Density	0.921 g/mL at 20 °C (lit.)
refractive index	n20/D 1.403
Flash point:	33 °C
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform (Sparingly), Methanol (Slightly)
pka	14.49±0.20(Predicted)
form	Liquid
color	Clear colorless
optical activity	[α]20/D +22±2°, c = 10% in chloroform
BRN	1718940
Stability:	Volatile
CAS DataBase Reference	26550-55-0

Safety information for (S)-(+)-1-Methoxy-2-propanol

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02
GHS Hazard Statements	H226:Flammable liquids H320:Serious eye damage/eye irritation H336:Specific target organ toxicity,single exposure; Narcotic effects
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P403+P235:Store in a well-ventilated place. Keep cool.