(S)-1-(4-Nitrophenyl)ethylamine hydrochloride

Synonym(s):(R)-1-(4-Nitrophenyl)ethylamine hydrochloride

CAS NO.：57233-86-0
Empirical Formula: C8H11ClN2O2
Molecular Weight: 202.64
MDL number: MFCD00066311
SAFETY DATA SHEET (SDS)
Update Date: 2022-11-11 11:01:00

(S)-1-(4-Nitrophenyl)ethylamine hydrochloride Structural

What is (S)-1-(4-Nitrophenyl)ethylamine hydrochloride?

Purification Methods

To ensure dryness, the hydrochloride (ca 175 g) is extracted with EtOH (3x100mL) and evaporated to dryness (any residual H2O increases the solubility in EtOH and lowers the yield). The hydrochloride residue is triturated with absolute EtOH and dried in vacuo. The product is further purified by refluxing with absolute EtOH (200 mL for 83g) for 1hour, and cool to 10o to give 76.6g of hydrochloride m 243-245o(dec). The free base is prepared by dissolving in N NaOH, extracting with CH2Cl2 (3 x 500mL), drying (Na2CO3), filtering, evaporating and distilling it. It has m 27o, b 119-120o/0.5mm (105-107o/0.5mm, 157-159o/9mm, d 1.1764, n 1.5688, [] ±17.7o (neat) [Perry et al. Synthesis 492 1977,ORD: Nerdel & Liebig Justus Liebigs Ann Chem 621 142 1959]. [Beilstein 12 IV 2451.]

Properties of (S)-1-(4-Nitrophenyl)ethylamine hydrochloride

Melting point:	248-250 °C(lit.)
alpha	-6.5 º (c=1, 0.05N NaOH)
storage temp.	Inert atmosphere,Room Temperature
optical activity	[α]25/D +6.0°, c = 1 in 0.05 M NaOH
BRN	3701567
CAS DataBase Reference	57233-86-0(CAS DataBase Reference)

Safety information for (S)-1-(4-Nitrophenyl)ethylamine hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.