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HomeProduct name listRUGULOSIN

RUGULOSIN

RUGULOSIN Structural

What is RUGULOSIN?

Description

(+)-Rugulosin is a pigment and mycotoxin produced by certain fungi. It inhibits HIV-1 integrase activity with IC50 values of 19 and 25 μM in coupled and strand transfer assays, respectively. It also inhibits ribonuclease H in rat liver by 83% at a concentration of 157 μM and ribonucleases H1, H2, and H3 in T. pyriformis by 100, 99, and 100%, respectively, at a concentration of 313 μM. (+)-Rugulosin leads to hepatic injury and liver cell hyperplasia in mice when administered in the diet. It is cytotoxic to insect cells but not mammalian C6/36, L929, and HepG2 cells (ID50s = 1.2, >200, 23.7, and >200 μg/ml, respectively).

The Uses of RUGULOSIN

(+)-Rugulosin is an intense yellow pigment produced by some species of Penicillium, Aspergillus and the fungal symbiotants of some lichens. (+)-Rugulosin shows antibacterial and insecticidal activity and has found application as a bioinsecticide, notably as the active secondary metabolite in endophytic fungi of seedlings.

The Uses of RUGULOSIN

Rugulosin (+ form) is an intense yellow pigment produced by Penicillium and Aspergillus.

What are the applications of Application

Rugulosin (+ form) is an intense yellow pigment produced by Penicillium and Aspergillus

Definition

ChEBI: Rugulosin is a cyclic ketone and an organic polycyclic compound.

Properties of RUGULOSIN

Melting point: 293℃ (decomposition)
Boiling point: 535.95°C (rough estimate)
Density  1.3164 (rough estimate)
refractive index  1.5376 (estimate)
storage temp.  Store at -20°C
solubility  DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form  A solid
pka 4.20±1.00(Predicted)
IARC 3 (Vol. 40, Sup 7) 1987
EPA Substance Registry System 5H,6H-6,13a,5a,14-[1,2,3,4]Butanetetraylcycloocta[1,2-b:5,6-b']dinaphthalene-5,8,13,16(14H)-tetrone, 1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-, (5aS,6R,13aS,14R,17S,18R,19R,20S)- (23537-16-8)

Safety information for RUGULOSIN

Computed Descriptors for RUGULOSIN

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