(RS)-2-AMINO-3-(4-CHLORO-3-HYDROXY-5-ISOXAZOLYL)PROPIONIC ACID

CAS NO.：909400-43-7
Empirical Formula: C6H7ClN2O4
Molecular Weight: 206.58
MDL number: MFCD04113776
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is (RS)-2-AMINO-3-(4-CHLORO-3-HYDROXY-5-ISOXAZOLYL)PROPIONIC ACID?

The Uses of (RS)-2-AMINO-3-(4-CHLORO-3-HYDROXY-5-ISOXAZOLYL)PROPIONIC ACID

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor), a heterotetrameric transmembrane receptor, is found in various areas of the brain and mediates fast synaptic transmission in the central nervous system (1). Cl-HIBO (chloro-homoibotenic acid) is a subtype selective AMPA receptor agonist (2).

What are the applications of Application

Cl-HIBO is Chloro-homoibotenic acid, a highly desensitising AMPA receptor agonist. Subtype selective for GluR1 and GluR2 subunit-containing receptors

Biological Activity

Subtype-selective and strongly desensitising AMPA receptor agonist; selective for GluR1 and GluR2 subunit-containing receptors (EC 50 values are 4.7, 1.7, 2700 and 1300 μ M for rat recombinant homomeric GluR1, 2, 3 and 4 receptors respectively).

Properties of (RS)-2-AMINO-3-(4-CHLORO-3-HYDROXY-5-ISOXAZOLYL)PROPIONIC ACID

Density	1.66±0.1 g/cm3(Predicted)
storage temp.	Store at RT
pka	2.26±0.10(Predicted)
form	Powder
Water Solubility	Soluble to 20 mM in water

Safety information for (RS)-2-AMINO-3-(4-CHLORO-3-HYDROXY-5-ISOXAZOLYL)PROPIONIC ACID

Computed Descriptors for (RS)-2-AMINO-3-(4-CHLORO-3-HYDROXY-5-ISOXAZOLYL)PROPIONIC ACID

New Products

4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium 3-Bromopyrazole (3aR,4R,5R,6aS)-hexahydro-5-Triethyl silyloxy-4-((E)-3-oxo-5-phenylpent-1- enyl)cyclopenta[b]furan-2-one. 1-Chlorocarbonyl-4-piperidinopiperidine 1-Bromo-4-phenyl-2-Butanone 4-Amino-2-fluoro-N-methylbenzamide 1,1'-Carbonyldiimidazole SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION