(RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID

CAS NO.：170847-18-4
Empirical Formula: C10H12NO5P
Molecular Weight: 257.18
MDL number: MFCD01321070
Update Date: 2024-07-02 08:54:57

What is (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID?

The Uses of (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID

(RS)-APICA is a group II metabotropic glutamate receptor antagonist.

Biological Activity

The rigidified analog of MPPG ((RS)-a-Methyl-4-phosphonophenylglycine ); a selective group II metabotropic glutamate receptor antagonist (IC 50 = 30 μ M) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses an unusual inverse agonist-like action.

Properties of (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID

Boiling point:	559.9±60.0 °C(Predicted)
Density	1?+-.0.1 g/cm3(Predicted)
storage temp.	Desiccate at +4°C
solubility	Soluble to 100 mM in 1.1eq. NaOH
form	Powder
pka	1.34±0.40(Predicted)
color	White to off-white

Safety information for (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID

Computed Descriptors for (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID

New Products

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