(RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID
- CAS NO.：170847-18-4
- Empirical Formula: C10H12NO5P
- Molecular Weight: 257.18
- MDL number: MFCD01321070
- Update Date: 2024-07-02 08:54:57
What is (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID?
The Uses of (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID
(RS)-APICA is a group II metabotropic glutamate receptor antagonist.
Biological Activity
The rigidified analog of MPPG ((RS)-a-Methyl-4-phosphonophenylglycine ); a selective group II metabotropic glutamate receptor antagonist (IC 50 = 30 μ M) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses an unusual inverse agonist-like action.
Properties of (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID
| Boiling point: | 559.9±60.0 °C(Predicted) |
| Density | 1?+-.0.1 g/cm3(Predicted) |
| storage temp. | Desiccate at +4°C |
| solubility | Soluble to 100 mM in 1.1eq. NaOH |
| form | Powder |
| pka | 1.34±0.40(Predicted) |
| color | White to off-white |
Safety information for (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID
Computed Descriptors for (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID
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