(RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID

CAS NO.：170847-18-4
Empirical Formula: C10H12NO5P
Molecular Weight: 257.18
MDL number: MFCD01321070
Update Date: 2024-07-02 08:54:57

What is (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID?

The Uses of (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID

(RS)-APICA is a group II metabotropic glutamate receptor antagonist.

Biological Activity

The rigidified analog of MPPG ((RS)-a-Methyl-4-phosphonophenylglycine ); a selective group II metabotropic glutamate receptor antagonist (IC 50 = 30 μ M) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses an unusual inverse agonist-like action.

Properties of (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID

Boiling point:	559.9±60.0 °C(Predicted)
Density	1?+-.0.1 g/cm3(Predicted)
storage temp.	Desiccate at +4°C
solubility	Soluble to 100 mM in 1.1eq. NaOH
form	Powder
pka	1.34±0.40(Predicted)
color	White to off-white

Safety information for (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID

Computed Descriptors for (RS)-1-AMINO-5-PHOSPHONOINDAN-1-CARBOXYLIC ACID

New Products

4-Fluorophenylacetic acid 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate (6-METHYL-[1,3]DITHIOLO[4,5-b]QUINOXALIN-2-ONE INDAZOLE-3-CARBOXYLIC ACID 4-IODO BENZOIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5,6-Dimethoxyindanone 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetate