Rituximab
Synonym(s):Monoclonal IgG1
- CAS NO.:174722-31-7
- Empirical Formula: C6416H9874N1688O1987S44
- Molecular Weight: 0
- Update Date: 2024-10-28 23:16:16
What is Rituximab?
Description
Rituximab, a chimeric murine/human monoclonal antibody approved in the United States only for treating refractory or relapsed B-cell lymphomas, reacts with the CD20 antigen. It contains the complementarity determining murine anti-CD20 antibody 2B8 regions in conjunction with human kappa and IgG1 heavy-chain constant region sequences. The vector was cloned into Chinese hamster ovarian cells as the production source of immunoglobulin. Rituximab is composed of two heavy chains of 451 amino acids and two light chains of 213 amino acids with a molecular weight of 145 kD. Rituximab has a binding affinity for the CD20 antigen of approximately 8.0 nM, similar to the parent murine antibody, 2B8[1].
The Uses of Rituximab
Rituximab is being used for Coronavirus-related infections.
The Uses of Rituximab
Antineoplastic (microtubule inhibitor); monoclonal antibody.
brand name
Rituxan (IDEC).
Mechanism of action
Rituximab has a unique mode of action and can induce the killing of CD20+ cells via multiple mechanisms. The direct effects of rituximab include complement-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity, and the indirect effects include structural changes, apoptosis, and sensitization of cancer cells to chemotherapy.
Clinical Use
Rituximab has seen use in transplant patients in several settings: (1) treatment of post-transplant lymphoproliferative disease (PTLD); (2) prevention of rejection; (3) ABO-incompatible transplantation; (4) treatment of rejection; (5) desensitization in HLA sensitized patients. The treatment of post-transplant lymphoproliferative disease has probably seen the greatest use of rituximab with great success. However, there is no formal indication of this use. In non-transplant patients with lymphoma, rituximab is typically combined with other chemotherapeutic agents with somewhat worse results.
Properties of Rituximab
storage temp. | Store at -80°C |
form | Liquid |
color | Colorless to light yellow |
Safety information for Rituximab
Computed Descriptors for Rituximab
New Products
Bromine 99.5% AR (4 x 500ml) Fehling's Solution No. B Amino Acid Kit of 23 items set Ammonium Molybdate Reagent Solution Beam's Reagent Solution Ehrlich's Reagent For detection of urobillinogen Sodium Amino Salicylate Dihydrate (PAS Sodium) IP/BP/USP/EP 1,2,3,4-Tetrahydrocarbazol-4-one 4-Hydroxy Carbazole Amino Salicylic Acid. U.S.P. 2 – Methoxy – 5- Sulfamoyl Benzoic acid Acetone Isobutryl oxime ester Curcuma aromatica Oil Curry leaf Extract Terminalia bellirica Extract Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract Ethyl 3-(Pyridin-2-Ylamino)Propanoate Bilastine -IP/BP/ Cypermethric Acid Chloride 5-Nitrosalicylaldehyde 5-(Difluoromethoxy)-2-Mercapto-1H-Benzimidazole- IP/BP/ Methyl Di Chloride (Mdc)Related products of tetrahydrofuran
You may like
-
USP mAb 001, Monoclonal IgG1 CAS 174722-31-7View Details
174722-31-7 -
7726-95-6 Bromine 99.5% AR (4 x 500ml) 99%View Details
7726-95-6 -
Formamide 99%View Details
75-12-7 -
2, 4-Pyrimidinediamine 3-Oxide 99%View Details
74638-76-9 -
111974-72-2 99%View Details
111974-72-2 -
85-81-4 6-Methoxy-8-Nitroquinoline 99%View Details
85-81-4 -
3-Bromo-4,5-Dihydro-1H-Benzo[B]Azepin-2(3H)-One 99%View Details
86499-96-9 -
(−)-Dip-Chloride 85116-37-6 99%View Details
85116-37-6