REVERSIN 121
Synonym(s):Boc-Asp(Obzl)-Lys(Z)-OtBu
- CAS NO.：174630-04-7
- Empirical Formula: C34H47N3O9
- Molecular Weight: 641.75
- MDL number: MFCD03788012
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is REVERSIN 121?
Description
Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a Kd value of 77 nM. Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma membrane vesicles from multidrug-resistant cells, and reconstituted proteoliposomes as well as in a variety of MDR1-expressing intact tumor cells.
The Uses of REVERSIN 121
Reversin 121 has been used to determine the activity of P-glycoprotein in human retinal pigment epithelium.
What are the applications of Application
Reversin 121 is an inhibitor of P-glycoprotein (MDR1)
General Description
Reversin 121 is an analog of reversin and a dipeptide derivative.
Biochem/physiol Actions
Peptide chemosensitizer, inhibitor of P-glycoprotein.
Properties of REVERSIN 121
| Boiling point: | 786.8±60.0 °C(Predicted) |
| Density | 1.163±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO or ethanol: soluble |
| form | powder |
| pka | 10.75±0.46(Predicted) |
| color | white |
Safety information for REVERSIN 121
Computed Descriptors for REVERSIN 121
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