REVERSIN 121

Synonym(s):Boc-Asp(Obzl)-Lys(Z)-OtBu

CAS NO.：174630-04-7
Empirical Formula: C34H47N3O9
Molecular Weight: 641.75
MDL number: MFCD03788012
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is REVERSIN 121?

Description

Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a K_d value of 77 nM. Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma membrane vesicles from multidrug-resistant cells, and reconstituted proteoliposomes as well as in a variety of MDR1-expressing intact tumor cells.

The Uses of REVERSIN 121

Reversin 121 has been used to determine the activity of P-glycoprotein in human retinal pigment epithelium.

What are the applications of Application

Reversin 121 is an inhibitor of P-glycoprotein (MDR1)

General Description

Reversin 121 is an analog of reversin and a dipeptide derivative.

Biochem/physiol Actions

Peptide chemosensitizer, inhibitor of P-glycoprotein.

Properties of REVERSIN 121

Boiling point:	786.8±60.0 °C(Predicted)
Density	1.163±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	DMSO or ethanol: soluble
form	powder
pka	10.75±0.46(Predicted)
color	white

Safety information for REVERSIN 121

Computed Descriptors for REVERSIN 121

New Products

4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acid