REVERSE T3

Chemical properties

Beige Powder

The Uses of REVERSE T3

Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus

The Uses of REVERSE T3

One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.

The Uses of REVERSE T3

Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus.

What are the applications of Application

3,3′,5′-Triiodo-L-thyronine is of interest for the early detection and treatment of drug-induced hypothyroidism or congenital in the developing human fetus

What are the applications of Application

3,3′,5-Triiodo-L-thyronine-13C6 is a compound involved in the maintenance of metabolic homeostasis

Definition

ChEBI: 3,3',5'-triiodo-L-thyronine is a 3,3',5'-triiodothyronine. It is a tautomer of a 3,3',5'-triiodo-L-thyronine zwitterion.

Biological Activity

3,3',5'-triiodo-l-thyronine (reverse t3 or rt3) and 3,5,3'-triiodo-l-thyronine (t3) are the metabolism of thyroxine (t4) [1]. 3,3',5'-triiodo-l-thyronine is thyroid hormone receptors trα and trβ antagonist [1].thyroid hormones play important roles in the development of the mammalian brain by acting on migration and differentiation of neural cells, synaptogenesis, and myelination. the actions of thyroid hormones are mediated by nuclear thyroid hormone receptors (trs) and regulation of gene expression. trs have been also involved in adult brain function. in adult mice, trα1 deletion and a dominant negative mutant receptor expression induce consistent behavioral changes leading to severe anxiety and morphological changes in the hippocampus [2].the rt3 was about 1,000-fold less active at the thyroid hormone receptors trα and trβ compared with 3,3',5-triiodo-l-thyronine and commonly described as inactive [1].it has been reported that rt3 activates a native form of trα, trδα1, which lacks a nuclear localization signal and functions in the cytoplasm. through this action, rt3 initiates actin polymerization, particularly in astrocytes and neurons [3].

References

[1] nicod p, burger a, staeheli v, et al. a radioimmunoassay for 3, 3′, 5′-triiodo-l-thyronine in unextracted serum: method and clinical results[j]. the journal of clinical endocrinology & metabolism, 1976, 42(5): 823-829.
[2] bernal j. thyroid hormone receptors in brain development and function[j]. nature clinical practice endocrinology & metabolism, 2007, 3(3): 249-259.
[3] senese r, cioffi f, de lange p, et al. thyroid: biological actions of ‘nonclassical’thyroid hormones[j]. journal of endocrinology, 2014, 221(2): r1-r12.