Remdesivir N-2

CAS NO.：1191237-80-5
Empirical Formula: C15H17N5O4
Molecular Weight: 331.33
MDL number: MFCD32693253
Update Date: 2024-07-02 08:55:01

What is Remdesivir N-2?

The Uses of Remdesivir N-2

Remdesivir N-2 can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in the research and development and chemical production of Remdesivir.

Synthesis

Synthesis_1191237-80-5
5.62g of compound GS-441524 was dissolved in 30mL of acetone, 11.50mL of 2,2-dimethoxypropane and 1.34mL of sulfuric acid were added, stirred at 45??C for half an hour, cooled to 25??C, and the organic solvent was removed by rotary evaporation. It was extracted with 100 mL of ethyl acetate and 100 mL of saturated sodium bicarbonate aqueous solution, and the extraction was repeated three times. The ethyl acetate layers were combined, dried by adding anhydrous sodium sulfate, and filtered to remove sodium sulfate. The organic solvent was removed by rotary evaporation, and column chromatography was performed (eluent: petroleum ether/ethyl acetate (V/V)=1/2) to obtain 6.20 g of compound 5 (white solid, 97% yield).

Properties of Remdesivir N-2

Density	1.66±0.1 g/cm3(Predicted)
solubility	DMSO:55.5(Max Conc. mg/mL);167.51(Max Conc. mM) Ethanol:5.0(Max Conc. mg/mL);15.09(Max Conc. mM) PBS (pH 7.2):0.3(Max Conc. mg/mL);0.91(Max Conc. mM) DMF:12.0(Max Conc. mg/mL);36.22(Max Conc. mM)
form	A solid
pka	14.14±0.10(Predicted)
color	Off-white to light yellow

Safety information for Remdesivir N-2

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.