(R)-TERT-BUTYL 2-(TOSYLOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE
- CAS NO.:128510-88-3
- Empirical Formula: C17H25NO5S
- Molecular Weight: 355.45
- MDL number: MFCD11505914
- SAFETY DATA SHEET (SDS)
- Update Date: 2022-08-26 12:27:02
What is (R)-TERT-BUTYL 2-(TOSYLOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE?
The Uses of (R)-TERT-BUTYL 2-(TOSYLOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE
tert-Butyl (R)-2-[[[(4-Methylphenyl)sulfonyl]oxy]methyl]-1-pyrrolidinecarboxylate is an intermediate in the synthesis of (2S)-Ethylpyrrolidine Hydrochloride (E818080), which is used as a reagent in the synthesis of N,N''-substituted-1,3-diamino-2-hydroxypropanes for treating Alzheimer''s disease. Also used as a reagent in the synthesis of cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK kinase inhibitors for treatment of autoimmune disease, cancer, inflammatory disease, and other diseases.
Properties of (R)-TERT-BUTYL 2-(TOSYLOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE
Boiling point: | 474.5±18.0 °C(Predicted) |
Density | 1?+-.0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
pka | -2.63±0.40(Predicted) |
Safety information for (R)-TERT-BUTYL 2-(TOSYLOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (R)-TERT-BUTYL 2-(TOSYLOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE
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