(R)-(+)-Ketorolac
Synonym(s):(+)-Ketorolac;(1R)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;;(R)-(+)-ketorolac;(R)-Ketorolac
- CAS NO.:66635-93-6
- Empirical Formula: C15H13NO3
- Molecular Weight: 255.27
- MDL number: MFCD00871492
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is (R)-(+)-Ketorolac?
Chemical properties
Off-White Solid
The Uses of (R)-(+)-Ketorolac
(R)-Ketorolac is the R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.
What are the applications of Application
(R)-Ketorolac is a prostaglandin biosynthesis inhibitor
Definition
ChEBI: A 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid that has R configuration. Unlike the S-enantiomer, it does not exhibit COX1 and COX2 inhibition, but does exhibit analgesic activity. Racemic keto olac, known simply as ketorolac, is used (mainly as a tromethamine salt) as a potent analgesic for the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.
Biochem/physiol Actions
R-Ketorolac is potent and selective Rho-family GTPases Cdc42 (cell division control protein 42) and Rac1 (Ras-related C3 botulinum toxin substrate 1) allosteric inhibitor that modulates downstream GTPase-dependent physiologic responses critical to tumor metastasis. R-ketorolac significantly inhibits ovarian cancer cell adhesion, migration, and invasion.
Properties of (R)-(+)-Ketorolac
Melting point: | 163-170°C |
storage temp. | -20°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | powder |
color | white to beige |
optical activity | [α]/D +162 to +178°, c = 1 in methanol |
Safety information for (R)-(+)-Ketorolac
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (R)-(+)-Ketorolac
New Products
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