R-(+)-DIOA
- CAS NO.：81166-47-4
- Empirical Formula: C20H24Cl2O4
- Molecular Weight: 399.31
- MDL number: MFCD00069261
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-30 08:29:57
What is R-(+)-DIOA?
The Uses of R-(+)-DIOA
R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system.
The Uses of R-(+)-DIOA
R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:
- short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
- uptake of grepafloxacin by THP-1 monocytes
- the uptake of moxifloxacin by THP-1 monocytes
What are the applications of Application
R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system
Biochem/physiol Actions
[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl?)?co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.
Properties of R-(+)-DIOA
| Melting point: | 173-174 °C |
| Boiling point: | 562.2±50.0 °C(Predicted) |
| Density | 1.307±0.06 g/cm3(Predicted) |
| solubility | H2O: insoluble <0.11mg/mL |
| form | solid |
| pka | 2.80±0.10(Predicted) |
| color | white |
| optical activity | [α]27/D +18.1°, c = 0.7 in methanol(lit.) |
Safety information for R-(+)-DIOA
Computed Descriptors for R-(+)-DIOA
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