(R)-(-)-ALPHA-METHYLHISTAMINE DIHYDROBROMIDE
- CAS NO.：75614-87-8
- Empirical Formula: C6H11N3
- Molecular Weight: 125.17
- MDL number: MFCD00209886
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is (R)-(-)-ALPHA-METHYLHISTAMINE DIHYDROBROMIDE?
Chemical properties
White to off-white solid
The Uses of (R)-(-)-ALPHA-METHYLHISTAMINE DIHYDROBROMIDE
R(-)-alpha-Methylhistamine is a potent agonist of the histamine H3-receptor.
Definition
ChEBI: An aralkylamino compound that is histamine bearing a methyl substituent at the alpha-position (the R-enantiomer).
Biological Activity
Very potent, high affinity H 3?agonist (K D = 50.3 nM) that displays > 200-fold selectivity over H 4 receptors. Inhibits H 3 -mediated histamine synthesis and release in the CNS and stimulates H 4 -mediated eosinophil shape change (EC 50 = 66 nM). Also available as part of the Histamine H 3 Receptor Tocriset™ .
Properties of (R)-(-)-ALPHA-METHYLHISTAMINE DIHYDROBROMIDE
| Density | 1.094 |
| storage temp. | Desiccate at RT |
| solubility | H2O: soluble |
| form | solid |
| color | white to off-white |
Safety information for (R)-(-)-ALPHA-METHYLHISTAMINE DIHYDROBROMIDE
Computed Descriptors for (R)-(-)-ALPHA-METHYLHISTAMINE DIHYDROBROMIDE
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