(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline

CAS NO.：927691-21-2
Empirical Formula: C22H21N5O3
Molecular Weight: 403.43
MDL number: MFCD12828216
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 09:03:09

What is (R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline?

Description

PQ-10 is a potent and selective inhibitor of phosphodiesterase type 10 (PDE10; K_i = 4 nM). It has >38-fold selectivity for PDE10 over a panel of 60 CNS-associated receptors, enzymes, and ion channels in vitro. Subcutaneous injection of PQ-10 (32 mg/kg) leads to increases in striatal cGMP and phosphorylation of cAMP response element binding protein (CREB) in murine striatum, known markers of in vivo PDE10 inhibition. PQ-10 at a dose of 0.3 mg/kg, p.o., reduces scopolamine- and MK-801-induced memory deficits in rats. PQ-10 also inhibits tumor cell growth with IC₅₀ values of 0.29 and 0.22 mM for HCT116 and SW480 colon cancer cells, respectively.

Biochem/physiol Actions

PQ-10 is a potent and selective inhibitor of phosphodiesterase 10A (PDE10). Apparently, PQ-10 enhances basic auditory information processing in rats. PQ-10 as other PED10 inhibitors suppresses a growth of human non-small cell lung cancer (NSCLC) cell lines.

Properties of (R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline

Density	1.333
storage temp.	2-8°C
solubility	DMSO: soluble10mg/mL, clear
form	powder
color	white to beige

Safety information for (R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline

Computed Descriptors for (R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline

New Products

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