(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE

Synonym(s):D-α,β-Isopropylideneglycerol-γ-tosylate;1,2-Isopropylidene-sn-glycerol 3-tosylate

CAS NO.：23788-74-1
Empirical Formula: C13H18O5S
Molecular Weight: 286.34
MDL number: MFCD00063233
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:37

(R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE Structural

What is (R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE?

Chemical properties

clear yellow to light brown viscous liquid

The Uses of (R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE

(R)-(-)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl p-Toluenesulfonate is a chiral building block. It is used to prepare the antifungal agent ketoconazole. It is also used to prepare acyclic Nucleotide Analogs Derived from 8-Azapurines with antiviral activities.

Properties of (R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE

Melting point:	41-43 °C(lit.)
Boiling point:	398.71°C (rough estimate)
Density	1.208 g/mL at 25 °C(lit.)
refractive index	n20/D 1.506(lit.)
Flash point:	>230 °F
storage temp.	-20°C
solubility	Dichloromethane; Chloroform; Ethyl Acetate; Methanol; DMF;
form	Oil
color	Pale Brown
optical activity	[α]/D 7.0±0.5°, neat
BRN	89800
CAS DataBase Reference	23788-74-1(CAS DataBase Reference)

Safety information for (R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection.