(R)-2-THIENYLGLYCINE
- CAS NO.:65058-23-3
- Empirical Formula: C6H7NO2S
- Molecular Weight: 157.19
- MDL number: MFCD00079612
- EINECS: 265-330-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2022-12-30 16:20:48
What is (R)-2-THIENYLGLYCINE?
Chemical properties
White to off-white powder
The Uses of (R)-2-THIENYLGLYCINE
(R)-2-Thienylglycine is a compound used in the one-pot regioselective synthesis of substituted arylglycines for kinetic resolution by penicillin G acylase.
Purification Methods
Recrystallise 2-(2-thienyl)glycine by dissolving it in H2O (1g in 3 mL), adjusting the pH to 5.5 with aqueous NH3, diluting with MeOH (20 mL), stirring, adjusting the pH to 5.5 and cooling to 0o. Also recrystallise it from small volumes of H2O. [R-isomer: Nishimura et al. Nippon Kagaku Zasshi 82 1688 1961, S-isomer: Johnson & Panetta Chem Abstr 63 14869 1965, Johnson & Hardcastle Chem Abstr 66 10930 1967, RS-isomer: LiBassi et al. Gazz Chim Ital 107 253 1977.] The (±) N-acetyl derivative has m 191o (from H2O) [Schouteenten et al. Bull Soc Chim Fr II 248, II 252 1978].
Properties of (R)-2-THIENYLGLYCINE
Boiling point: | 311.8±32.0 °C(Predicted) |
Density | 1.418±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C(protect from light) |
pka | 1.88±0.10(Predicted) |
Safety information for (R)-2-THIENYLGLYCINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H332:Acute toxicity,inhalation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P330:Rinse mouth. P363:Wash contaminated clothing before reuse. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P501:Dispose of contents/container to..… |
Computed Descriptors for (R)-2-THIENYLGLYCINE
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