(R)-2-Methyl-pyrrolidine
- CAS NO.:41720-98-3
- Empirical Formula: C5H11N
- Molecular Weight: 85.15
- MDL number: MFCD07783026
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-31 14:48:13
What is (R)-2-Methyl-pyrrolidine?
The Uses of (R)-2-Methyl-pyrrolidine
It is used as a building block used in a multikilogram synthesis of a chiral naphthalenoid histamine receptor antagonist.
Definition
ChEBI: (R)-2-methylpyrrolidine is a 2-methylpyrrolidine that has (R)-configuration. It is a conjugate base of a (R)-2-methylpyrrolidinium.
What are the applications of Application
(R)-2-Methyl-pyrrolidine, an optically active amine that can be used as a key building block to synthesize:
4,5-fused pyridazinone derivatives are applicable as potent histamine H3 receptor antagonists.
Naphthalenoid histamine H3 receptor antagonist.
Pyrrolo[2,3-d]pyrimidine derivatives as potent inhibitors of leucine-rich repeat kinase 2.
References
Synthesis and structure-activity relationships of 4,5-fused pyridazinones as histamine H3 receptor antagonists. DOI:10.1016/j.bmcl.2011.08.045
Efficient and Practical Synthesis of (R)-2-Methylpyrrolidine DOI:10.1021/jo060319n
Properties of (R)-2-Methyl-pyrrolidine
Boiling point: | 94 °C(Press: 728 Torr) |
Density | 0.842 |
refractive index | 1.4353 |
Flash point: | 45 ºF |
storage temp. | 2-8°C |
pka | 10.93±0.10(Predicted) |
color | Colourless to pale yellow |
Water Solubility | Insoluble in water. |
CAS DataBase Reference | 41720-98-3(CAS DataBase Reference) |
Safety information for (R)-2-Methyl-pyrrolidine
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H225:Flammable liquids H302:Acute toxicity,oral H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (R)-2-Methyl-pyrrolidine
New Products
(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin E Tubulysin G Tubulysin I Diethyl Aluminium Cyanide (1.0 M in Toluene) tetrahydro-4-methyl-2H-pyran 3-Aminocyclobutanone hydrochloride 4-(Benzyloxy)-3-bromophenylacetic Acid 4,4-DIFLUOROPIPERIDINE Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Imeglimin Hydrochloride IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell 2-(2-Formylphenoxy) acetic acid 2,3-dichloro-6- nitrobenzonitrile Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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