(R)-(-)-2-Amino-1-propanol
Synonym(s):D -Alaninol
- CAS NO.：35320-23-1
- Empirical Formula: C3H9NO
- Molecular Weight: 75.11
- MDL number: MFCD00064413
- EINECS: 629-219-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-11 18:14:38
What is (R)-(-)-2-Amino-1-propanol?
Chemical properties
Colorless to light yellow liqui
The Uses of (R)-(-)-2-Amino-1-propanol
(R)-(-)-2-Amino-1-propanol has been used as a derivatizing agent for gossypol during the analysis of gossypol enantiomers in cottonseed by high-performance liquid chromatography.
What are the applications of Application
R)-(-)-2-Amino-1-propanol is used as a chiral intermediate for the synthesis of pharmaceutical products and agrochemicals. It acts as additives in health care products and animal feed. It is a amino alcohol
obtained by reduction of d-alanine. This compound could be converted into the corresponding nonracemic
adenine derivative (R)-9-(1-Methyl-2-hydroxyethyl)adenine through minor variations on the classic
Montgomery sequence[1].
General Description
(R)-(-)-2-Amino-1-propanol is a chiral secondary amine.
References
[1] Jeffery A, et al. Synthesis of Acyclic Nucleoside and Nucleotide Analogues from Amino Acids: A Convenient Approach to a PMEA±PMPA Hybrid. Tetrahedron, 2000; 56: 5077-5083.
Properties of (R)-(-)-2-Amino-1-propanol
| Melting point: | 8 °C |
| Boiling point: | 173-176 °C(lit.) |
| alpha | -17 º (c=neat) |
| Density | 0.965 |
| refractive index | n |
| Flash point: | 183 °F |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Oily Liquid |
| pka | 12.88±0.10(Predicted) |
| color | Clear colorless to light yellow |
| Specific Gravity | 0.965 |
| optical activity | [α]19/D 18°, neat |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| BRN | 1718866 |
| CAS DataBase Reference | 35320-23-1(CAS DataBase Reference) |
| NIST Chemistry Reference | (R)-(-)-2-Amino-1-propanol(35320-23-1) |
Safety information for (R)-(-)-2-Amino-1-propanol
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for (R)-(-)-2-Amino-1-propanol
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product: 35320-23-1 D-Alaninol, 98% [(R)-(-)-2-Amino-1-propanol] 98%
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