(R)-(-)-1,3-Butanediol

CAS NO.：6290-03-5
Empirical Formula: C4H10O2
Molecular Weight: 90.12
MDL number: MFCD00064277
EINECS: 228-532-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-12 15:22:20

What is (R)-(-)-1,3-Butanediol?

Chemical properties

Colorless to light yellow liqui

The Uses of (R)-(-)-1,3-Butanediol

(R)-(-)-1,3-Butanediol is used as a solvent for food flavoring agents and is a co-monomer used in certain polyurethane and polyester resins.

Definition

ChEBI: A butane-1,3-diol of R-configuration.

What are the applications of Application

(R)-(-)-1,3-Butanediol is a chiral reagent used in the synthesis of pharmaceuticals including the preparation of (-)-tarchonanthuslactone, a δ-lactone skeleton based compound with antiroliferative activity on cancer cell.

Flammability and Explosibility

Not classified

References

Novaes, L. et al.: ChemMedChem., 10, 1687 (2015);
Akinobu Matsuyama; Hiroaki Yamamoto; Naoki Kawada; Yoshinori Kobayashi. Industrial production of (R)-1,3-butanediol by new biocatalysts.Journal of Molecular Catalysis B: Enzymatic.2001,11(4-6), 513-521.
Naoki Ichikawa; Satoshi Sato; Ryoji Takahashi; Toshiaki Sodesawa; Harunori Fujita; Takashi Atoguchi; Akinobu Shiga. Theoretical investigation of 1,3-butanediol adsorption on an oxygen-defected CeO2(111) surface.Journal of Catalysis.2006,239(1), 13-22.

Properties of (R)-(-)-1,3-Butanediol

Melting point:	0.07°C (estimate)
Boiling point:	107-110 °C/23 mmHg (lit.)
alpha	-31 º (c=1 in EtOH)
Density	1.005 g/mL at 25 °C (lit.)
vapor density	3.1 (vs air)
vapor pressure	0.06 mm Hg ( 20 °C)
refractive index	1.44
Flash point:	250 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, Ethanol
form	Oil
pka	14.83±0.20(Predicted)
color	Clear Colourless
optical activity	[α]21/D 31.0°, c = 1 in ethanol
Water Solubility	Fully miscible in water.
Sensitive	Hygroscopic
BRN	1718944
CAS DataBase Reference	6290-03-5(CAS DataBase Reference)
NIST Chemistry Reference	1,3-Butanediol, (R)-(6290-03-5)
EPA Substance Registry System	1,3-Butanediol, (3R)- (6290-03-5)

Safety information for (R)-(-)-1,3-Butanediol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection.