QUINUCLIDINE
Synonym(s):1-Azabicyclo[2.2.2]octane;ABCO
- CAS NO.：100-76-5
- Empirical Formula: C7H13N
- Molecular Weight: 111.18
- MDL number: MFCD00006690
- EINECS: 202-887-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:36
What is QUINUCLIDINE?
The Uses of QUINUCLIDINE
Quinuclidine acts as a catalyst, a chemical building block and is used in organic synthesis. It is employed to prepare quinine and alkaloids. It finds application as a ligand, which is useful in the studies of OsO4-catalyzed dihydroxylation of olefins. It plays an important role in the formation of onium salts used testing of PAC-antagonist activity.
Definition
ChEBI: Quinuclidine is a saturated organic heterobicyclic parent and a member of quinuclidines.
Hazard
A poison by ingestion and skin contact. Low toxicity by inhalation. A moderate skin and severe eye irritant.
Purification Methods
Crystallise it from diethyl ether. The hydrochloride has m 364-365o(dec) (from EtOH or n-BuOH), and the picrate has m 225o (from aqueous EtOH). [Beilstein 20 H 144, 20 II 71, 20 III/IV 1966, 20/4 V 335.]
Properties of QUINUCLIDINE
| Melting point: | 157-160 °C (lit.) |
| Boiling point: | 198.35°C (rough estimate) |
| Density | 0.8928 (rough estimate) |
| vapor pressure | 1.5 mm Hg ( 20 °C) |
| refractive index | 1.4500 (estimate) |
| solubility | H2O: very slightly soluble |
| form | powder to crystal |
| pka | 10.87±0.33(Predicted) |
| color | White to Light yellow |
| Water Solubility | Soluble in alcohol, diethyl ether, water and organic solvents. |
| Sensitive | Air Sensitive |
| Merck | 14,8081 |
| BRN | 103111 |
| CAS DataBase Reference | 100-76-5(CAS DataBase Reference) |
| EPA Substance Registry System | 1-Azabicyclo[2.2.2]octane (100-76-5) |
Safety information for QUINUCLIDINE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H310:Acute toxicity,dermal H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for QUINUCLIDINE
| InChIKey | SBYHFKPVCBCYGV-UHFFFAOYSA-N |
New Products
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