Quinaldic acid

Chemical properties

light brown needle-like crystalline powder

The Uses of Quinaldic acid

For the determination of copper, zinc and uranium with which it forms insoluble salts.

The Uses of Quinaldic acid

2-?Quinolinecarboxylic acid can be found in the studying of ligands for the purpose of copper-catalyzed Ullmann reactions with aryl ethers and aryl iodides.

Definition

ChEBI: A quinolinemonocarboxylic acid having the carboxy group at the 2-position.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1840, 1946 DOI: 10.1021/ja01213a045

General Description

Quinaldic acid is also referred as quinoline-2-carboxylic acid. Microwave-assisted preparation of substituted anilides of quinaldic acid has been reported. It inhibits the oxidation of pyruvate, α-ketoglutarate, glutamate and citrate in rat liver mitochondria. Quinaldic acid is a metabolite of tryptophan degradation and inhibits the gluconeogenesis in perfused livers.

Purification Methods

Crystallise quinaldic acid from *C6H6 or AcOH. It is used for the estimation of many metals. The methyl ester has m 86-87o (from hexane) and pK25 1.76. [Chauduri et al. Frez Z Anal Chem 281 361 1976, Beilstein 22 H 71, 22 II 55, 22 III/IV 1149, 22/3 V 183.]