PSEUDOLARIC ACID B
Synonym(s):(-)-Pseudolaric acid B;O-Acetylpseudolaric acid C;Pseudolarix acid B
- CAS NO.：82508-31-4
- Empirical Formula: C23H28O8
- Molecular Weight: 432.46
- MDL number: MFCD01746346
- EINECS: 231-291-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is PSEUDOLARIC ACID B?
Description
Pseudolaric acid B (PAB) is a diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant. It has reported antifungal activities, consistent with its traditional use in the treatment of dermatological fungal infections. Moreover, PAB has diverse effects that are relevant to cancer therapy, including inducing apoptosis of cancer cells (IC50 = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo.
The Uses of PSEUDOLARIC ACID B
(-)-Pseudolaric Acid B is a diterpenoid posessing an immunomodulatory effect. It acts as an immunosuppressant in vitro/vivo however does show some cytotoxicity. Anti-tumor agent as well.
What are the applications of Application
Pseudolaric acid B is a PPARα and PLC activator
Definition
ChEBI: Pseudolaric acid B is a diterpene lactone.
Properties of PSEUDOLARIC ACID B
| Melting point: | 166°C |
| Boiling point: | 466.14°C (rough estimate) |
| Density | 1.2108 (rough estimate) |
| refractive index | 1.4480 (estimate) |
| storage temp. | 2-8°C |
| solubility | methanol: soluble1mg/mL, clear, colorless |
| pka | 4.52±0.19(Predicted) |
| form | powder or crystals |
| color | white to off-white |
Safety information for PSEUDOLARIC ACID B
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. |
Computed Descriptors for PSEUDOLARIC ACID B
| InChIKey | VDGOFNMYZYBUDT-YCONPBHISA-N |
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