PROTOVERATRINE A
- CAS NO.：143-57-7
- Empirical Formula: C41H63NO14
- Molecular Weight: 793.94
- MDL number: MFCD00135586
- EINECS: 205-602-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:22
What is PROTOVERATRINE A?
Description
A further alkaloid isolated from Veratrum album, this base yields colourless crystals from EtOH. It is laevorotatory with [α]27D - 44.1° (pyridine) or - 12.1° (CHC13). Like the preceding base, it dissolves in H2S04 to give a blue colour. The complex with maleic acid has been prepared as colourless crystals, m.p. 241.5°C; [α]20D - 37.6°. On alkaline hydrolysis, the alkaloid furnishes protoverine, two moles of acetic acid, one mole of (-)-methylbutyric acid and one mole of (+)-2-hydroxy-2-methylbutyric acid.
The Uses of PROTOVERATRINE A
Protoveratrine A is a pharmacological agent which displays neuroprotective effects in ischemic stroke.
Definition
ChEBI: Protoveratrine A is an alkaloid.
brand name
Protalba (Marion Merrell Dow).
References
Stoll, Seebeck., Helv. Chim. Acta, 36,718 (1953)
Properties of PROTOVERATRINE A
| Melting point: | 267-269°C |
| alpha | D25 -40.5° (pyridine); D25 -10.5° (chloroform) |
| Boiling point: | 747.91°C (rough estimate) |
| Density | 1.36±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.6220 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | powder |
| pka | 10.74±0.70(Predicted) |
| color | White |
Safety information for PROTOVERATRINE A
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| Precautionary Statement Codes |
P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for PROTOVERATRINE A
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