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HomeProduct name listPROTOVERATRINE A

PROTOVERATRINE A

  • CAS NO.:143-57-7
  • Empirical Formula: C41H63NO14
  • Molecular Weight: 793.94
  • MDL number: MFCD00135586
  • EINECS: 205-602-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-15 10:43:22
PROTOVERATRINE A Structural

What is PROTOVERATRINE A?

Description

A further alkaloid isolated from Veratrum album, this base yields colourless crystals from EtOH. It is laevorotatory with [α]27D - 44.1° (pyridine) or - 12.1° (CHC13). Like the preceding base, it dissolves in H2S04 to give a blue colour. The complex with maleic acid has been prepared as colourless crystals, m.p. 241.5°C; [α]20D - 37.6°. On alkaline hydrolysis, the alkaloid furnishes protoverine, two moles of acetic acid, one mole of (-)-methylbutyric acid and one mole of (+)-2-hydroxy-2-methylbutyric acid.

The Uses of PROTOVERATRINE A

Protoveratrine A is a pharmacological agent which displays neuroprotective effects in ischemic stroke.

Definition

ChEBI: Protoveratrine A is an alkaloid.

brand name

Protalba (Marion Merrell Dow).

References

Stoll, Seebeck., Helv. Chim. Acta, 36,718 (1953)

Properties of PROTOVERATRINE A

Melting point: 267-269°C
alpha  D25 -40.5° (pyridine); D25 -10.5° (chloroform)
Boiling point: 747.91°C (rough estimate)
Density  1.36±0.1 g/cm3 (20 ºC 760 Torr)
refractive index  1.6220 (estimate)
storage temp.  2-8°C
solubility  Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form  powder
pka 10.74±0.70(Predicted)
color  White

Safety information for PROTOVERATRINE A

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
Precautionary Statement Codes P262:Do not get in eyes, on skin, or on clothing.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for PROTOVERATRINE A

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