PROTOVERATRINE A

CAS NO.：143-57-7
Empirical Formula: C41H63NO14
Molecular Weight: 793.94
MDL number: MFCD00135586
EINECS: 205-602-9
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-15 10:43:22

What is PROTOVERATRINE A?

Description

A further alkaloid isolated from Veratrum album, this base yields colourless crystals from EtOH. It is laevorotatory with [α]²⁷_D - 44.1° (pyridine) or - 12.1° (CHC13). Like the preceding base, it dissolves in H2S04 to give a blue colour. The complex with maleic acid has been prepared as colourless crystals, m.p. 241.5°C; [α]²⁰_D - 37.6°. On alkaline hydrolysis, the alkaloid furnishes protoverine, two moles of acetic acid, one mole of (-)-methylbutyric acid and one mole of (+)-2-hydroxy-2-methylbutyric acid.

The Uses of PROTOVERATRINE A

Protoveratrine A is a pharmacological agent which displays neuroprotective effects in ischemic stroke.

Definition

ChEBI: Protoveratrine A is an alkaloid.

brand name

Protalba (Marion Merrell Dow).

References

Stoll, Seebeck., Helv. Chim. Acta, 36,718 (1953)

Properties of PROTOVERATRINE A

Melting point:	267-269°C
alpha	D25 -40.5° (pyridine); D25 -10.5° (chloroform)
Boiling point:	747.91°C (rough estimate)
Density	1.36±0.1 g/cm3 (20 ºC 760 Torr)
refractive index	1.6220 (estimate)
storage temp.	2-8°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	powder
pka	10.74±0.70(Predicted)
color	White

Safety information for PROTOVERATRINE A

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
Precautionary Statement Codes	P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection.