Propionyl-L-carnitine hydrochloride
Synonym(s):(2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt;L -Carnitine propionyl ester;C3-Carnitine;Propanoyl-L -carnitine
- CAS NO.:119793-66-7
- Empirical Formula: C10H20ClNO4
- Molecular Weight: 253.72
- MDL number: MFCD00274137
- EINECS: 922-939-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-07 21:39:59
What is Propionyl-L-carnitine hydrochloride?
Description
Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids. Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; ) and 6-keto-prostaglandin F1α in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; ) in non-contaminated cells. It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal. Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.
Chemical properties
White Solid
The Uses of Propionyl-L-carnitine hydrochloride
L-Propionyl carnitine has been shown to improve the heart's mechanical recovery and other metabolic parameters after ischemia-reperfusion.
The Uses of Propionyl-L-carnitine hydrochloride
antihypertensive
The Uses of Propionyl-L-carnitine hydrochloride
L-Propionyl carnitine has been shown to improve the heart''s mechanical recovery and other metabolic parameters after ischemia-reperfusion.
What are the applications of Application
(R)-Propionyl Carnitine Chloride is a cardiology reagent
What are the applications of Application
Propionyl L-carnitine hydrochloride is plays a role in mitochondrial metabolism and demonstrates beneficial cardiovascular effects
brand name
Dromos (Biosint S.p.A.).
storage
+4°C
Properties of Propionyl-L-carnitine hydrochloride
Melting point: | 165-167°C |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | Chloroform (Slightly), Water (Slightly) |
form | Solid |
color | White to Off-White |
Stability: | Hygroscopic |
CAS DataBase Reference | 119793-66-7(CAS DataBase Reference) |
Safety information for Propionyl-L-carnitine hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Propionyl-L-carnitine hydrochloride
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