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HomeProduct name listPropionyl-L-carnitine hydrochloride

Propionyl-L-carnitine hydrochloride

Synonym(s):(2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt;L-Carnitine propionyl ester;C3-Carnitine;Propanoyl-L-carnitine

  • CAS NO.:119793-66-7
  • Empirical Formula: C10H20ClNO4
  • Molecular Weight: 253.72
  • MDL number: MFCD00274137
  • EINECS: 922-939-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-07 21:39:59
Propionyl-L-carnitine hydrochloride Structural

What is Propionyl-L-carnitine hydrochloride?

Description

Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids. Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; ) and 6-keto-prostaglandin F in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; ) in non-contaminated cells. It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal. Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.

Chemical properties

White Solid

The Uses of Propionyl-L-carnitine hydrochloride

L-Propionyl carnitine has been shown to improve the heart's mechanical recovery and other metabolic parameters after ischemia-reperfusion.

The Uses of Propionyl-L-carnitine hydrochloride

antihypertensive

The Uses of Propionyl-L-carnitine hydrochloride

L-Propionyl carnitine has been shown to improve the heart''s mechanical recovery and other metabolic parameters after ischemia-reperfusion.

What are the applications of Application

(R)-Propionyl Carnitine Chloride is a cardiology reagent

What are the applications of Application

Propionyl L-carnitine hydrochloride is plays a role in mitochondrial metabolism and demonstrates beneficial cardiovascular effects

brand name

Dromos (Biosint S.p.A.).

storage

+4°C

Properties of Propionyl-L-carnitine hydrochloride

Melting point: 165-167°C
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  Chloroform (Slightly), Water (Slightly)
form  Solid
color  White to Off-White
Stability: Hygroscopic
CAS DataBase Reference 119793-66-7(CAS DataBase Reference)

Safety information for Propionyl-L-carnitine hydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Propionyl-L-carnitine hydrochloride

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