Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
- CAS NO.：1391728-01-0
- Empirical Formula: C16H29N2O4P
- Molecular Weight: 344.39
- MDL number: MFCD28142480
- Update Date: 2023-07-14 17:32:04
What is Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite?
Biological Activity
Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
| Boiling point: | 387.2±37.0 °C(Predicted) |
| pka | 3.53±0.70(Predicted) |
Safety information for Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
Computed Descriptors for Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
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