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HomeProduct name listPropargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite

Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite

  • CAS NO.:1391728-01-0
  • Empirical Formula: C16H29N2O4P
  • Molecular Weight: 344.39
  • MDL number: MFCD28142480
  • Update Date: 2023-07-14 17:32:04
Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Structural

What is Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite?

Biological Activity

Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Properties of Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite

Boiling point: 387.2±37.0 °C(Predicted)
pka 3.53±0.70(Predicted)

Safety information for Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite

Computed Descriptors for Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite

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