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HomeProduct name listPREGNENOLONE SULFATE SODIUM SALT

PREGNENOLONE SULFATE SODIUM SALT

Synonym(s):3β-Hydroxy-5-pregnen-20-one 3-sulfate;3-Hydroxypregn-5-en-20-one sulfate;5-Pregnen-3β-ol-20-one sulfate

PREGNENOLONE SULFATE SODIUM SALT Structural

What is PREGNENOLONE SULFATE SODIUM SALT?

Description

Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone . Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3).

The Uses of PREGNENOLONE SULFATE SODIUM SALT

Pregnenolone Sulfate Sodium Salt, is a metabolite of Pregnenolone (P712200). It is also a neuroactive steroid, a potent and efficacious modulators of the GABAA receptor.

The Uses of PREGNENOLONE SULFATE SODIUM SALT

Pregnenolone sulfate sodium salt has been used as sigma-1 receptor (σ1R) agonist. It has also been used in the stimulation and as a ligand for transient receptor potential melastatin-3 (TRPM3).

What are the applications of Application

Pregnenolone sulfate sodium salt is is a GABAA receptor antagonist

Biochem/physiol Actions

Pregnenolone sulfate is a neurosteroid and a neuromodulator. It is involved in the stimulation of N-methyl-D-aspartate receptor (NMDA), γ-Aminobutyric acid type A (GABAA?) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-kainate). It activates transient receptor potential melastatin (TRPM3) which is a calcium-permeable ion channel. It improves schizophrenia and behavioral anomalies by modulating NMDA mediated Ser/Thr kinase - glycogen synthase kinase 3 β (AKT/GSK3β) signaling pathway.

storage

Store at +4°C

Properties of PREGNENOLONE SULFATE SODIUM SALT

Melting point: 192 °C(lit.)
storage temp.  Store at -20°C
solubility  methanol and water: 1.93 mg/mL
form  A crystalline solid
color  White to off-white

Safety information for PREGNENOLONE SULFATE SODIUM SALT

Computed Descriptors for PREGNENOLONE SULFATE SODIUM SALT

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