Ponazuril

Synonym(s):1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

CAS NO.：69004-04-2
Empirical Formula: C18H14F3N3O6S
Molecular Weight: 457.38
MDL number: MFCD09263475
EINECS: 629-740-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

What is Ponazuril?

Description

Toltrazuril sulfone is an active metabolite of the coccidiostat toltrazuril . Toltrazuril sulfone is formed from toltrazuril via the intermediate metabolite toltrazuril sulfoxide by cytochrome P450 (CYP) enzymes, including CYP3A. It inhibits T. gondii tachyzoite production in African green monkey kidney cells when used at concentrations of 0.1, 1, and 5 μg/ml. Toltrazuril sulfone completely prevents infection with T. gondii tachyzoites in a mouse model of fatal toxoplasmosis when administered at doses of 10 or 20 mg/kg one day prior to, and daily for 10 days following, infection. It also reduces the number of infected mice in the same model when administered at a dose of 10 mg/kg for 11 days starting six days following infection. Formulations containing toltrazuril sulfone have been used in the treatment of equine protozoal myeloencephalitis (EPM) in horses.

The Uses of Ponazuril

Toltrazuril sulfone is antiprotazoal, used to treat Equine Protozoal Myeloencephalitis (EPM).

What are the applications of Application

Toltrazuril sulfone is an antiprotozoal

Veterinary Drugs and Treatments

Ponazuril is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona.
Ponazuril could potentially be useful in treating Neospora caninum and Toxoplasma infections in dogs or cats.

Properties of Ponazuril

Melting point:	242°
Density	1.507±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	Acetontrile (Slightly), DMSO (Slightly), Methanol (Slightly)
form	neat
pka	6.46±0.20(Predicted)
form	Solid
color	White to Off-White
CAS DataBase Reference	69004-04-2

Safety information for Ponazuril

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.