POLYPHYLLIN D
- CAS NO.：50773-41-6
- Empirical Formula: C44H70O16
- Molecular Weight: 855.02
- MDL number: MFCD12407435
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-27 18:15:55
What is POLYPHYLLIN D?
Description
Polyphyllin I is a steroid saponin that has been found in P. polyphylla and has anticancer activity. It decreases proliferation of, and induces apoptosis in, MCF-7 and MDA-MB-231 cells (IC50s = 5 and 2.5 μM, respectively). It disrupts the mitochondrial membrane potential, activates caspase-3, and increases protein levels of the caspase-3 substrate poly(ADP-ribose) polymerase (PARP) in HepG2 and drug-resistant R-HepG2 cells. Polyphyllin I (2.05 and 2.73 mg/kg for 10 days) reduces tumor growth in an MCF-7 mouse xenograft model.
The Uses of POLYPHYLLIN D
Polyphylin II is a natural saponin extracted from the plant, Paris polyphylla, and displays antiproliferative activity in vivo. Used in the treatment of lung and cervical cancers.
Properties of POLYPHYLLIN D
| Melting point: | >245°C (dec.) |
| Density | 1.40 |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated), Pyridine (Slightly) |
| form | Solid |
| pka | 12?+-.0.70(Predicted) |
| color | White |
Safety information for POLYPHYLLIN D
Computed Descriptors for POLYPHYLLIN D
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