Polyoxyethylene lauryl ether

Absorption

When given intravenously, the maximum blood concentrations were reached in 15 mins.

Toxicity

Most adverse reactions are related to the intravenous administration such as local irritation, pain, and hematoma. Extravasation can also be an issue.

Chemical properties

White or almost white, unctuous and hygroscopic mass, melting at 24 °C into a colourless or yellowish, viscous liquid.

The Uses of Polyoxyethylene lauryl ether

Ethosperse(R) LA-4 is a medium range HLB, ethoxylated, nonionic ether of lauryl alcohol with broad range pH stability. It is suggested for use as an emulsifier in cosmetics to add body and texture (humectant), in household products and in lubricants.

The Uses of Polyoxyethylene lauryl ether

Solvent; nonionic emulsifier; pharmaceutic aid (surfactant); spermaticide.

The Uses of Polyoxyethylene lauryl ether

Brij L23 is a a pharmaceutical compound used in the schlerotherapy treatments, in those suffering from blood vessel malformations and mutations.

What are the applications of Application

Brij 35 is for isolation of functional cell membrane complexes

Indications

Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins and uncomplicated reticular veins in the lower extremity.

Background

Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins ≤1 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity. It is marketed under the brand names Asclera and Varithena. The formula for Polidocanol has the structural formula C12H25(OCH2CH2)nOH, a mean extent of polymerization (n) of approximately 9 and a mean molecular weight of approximately 600.

Production Methods

The method for producing a Polyoxyethylene Lauryl Ether, which comprises a sulfation step wherein an ethylene oxide addition product of an alkyl alcohol having 8-22 carbon atoms is reacted with an SO3-containing gas, thereby obtaining a sulfated product of the ethylene oxide addition product, and a neutralization step wherein the sulfated product is neutralized, thereby obtaining a sulfate. The ethylene oxide addition product contains from 0.01% by mass to 1% by mass (inclusive) of an alkali metal hydroxide relative to the total mass of the ethylene oxide addition product.

brand name

Brij 30 (ICI Americas).

General Description

Clear colorless to light yellow viscous liquid. Colorless at 266°F; brown at 644°F. Bland odor.

Air & Water Reactions

Water soluble.

Reactivity Profile

Polyoxyethylene lauryl ether is incompatible with strong oxidizing agents and strong bases.

Fire Hazard

Polyoxyethylene lauryl ether is combustible.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Brij? L23 also referred to as Brij 35 or Polyoxyethylene (23) lauryl ether is a non-ionic detergent that lowers the non-specific protein adsorption and reduces electroosmotic pumping drastically. This allows the pH to be varied without adversely affecting the flow rate. It also used as a nonionic surfactant that decreases the absorbance of the blank, inhibits turbidity as well as provides linearity.

Pharmacokinetics

Polidocanol has a concentration and volume dependent damaging effect on the blood vessel endothelium.

Metabolism

Metabolism was not measured.