Polyoxyethylene lauryl ether

Synonym(s):Brij 35;Polidocanol;Lauromacrogol;Polyethylene glycol dodecyl ether;Coceth-10

CAS NO.：9002-92-0
Empirical Formula: C58H118O24
Molecular Weight: 1199.55
MDL number: MFCD00043375
EINECS: 500-002-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-16 10:38:43

Polyoxyethylene lauryl ether Structural Picture

What is Polyoxyethylene lauryl ether?

Absorption

When given intravenously, the maximum blood concentrations were reached in 15 mins.

Toxicity

Most adverse reactions are related to the intravenous administration such as local irritation, pain, and hematoma. Extravasation can also be an issue.

The Uses of Polyoxyethylene lauryl ether

Ethosperse(R) LA-4 is a medium range HLB, ethoxylated, nonionic ether of lauryl alcohol with broad range pH stability. It is suggested for use as an emulsifier in cosmetics to add body and texture (humectant), in household products and in lubricants.

What are the applications of Application

Brij 35 is for isolation of functional cell membrane complexes

Indications

Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins and uncomplicated reticular veins in the lower extremity.

Background

Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins ≤1 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity. It is marketed under the brand names Asclera and Varithena. The formula for Polidocanol has the structural formula C12H25(OCH2CH2)nOH, a mean extent of polymerization (n) of approximately 9 and a mean molecular weight of approximately 600.

Pharmacokinetics

Polidocanol has a concentration and volume dependent damaging effect on the blood vessel endothelium.

Metabolism

Metabolism was not measured.

Properties of Polyoxyethylene lauryl ether

Melting point:	41-45 °C(lit.)
Boiling point:	100 °C(lit.)
Density	0.99 g/mL±0.002 g/mL at 20 °C
Flash point:	>230 °F
storage temp.	Store below +30°C.
solubility	H₂O: 40 mg/mL at 20 °C, clear, colorless
form	Waxy Pellets
color	White
Odor	Odorless
Water Solubility	soluble
FreezingPoint	35.0 to 40.0 ℃

Safety information for Polyoxyethylene lauryl ether

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.