Pidotimod

Synonym(s):(4R)-3-(5-Oxo-L-prolyl)-1,3-thiazolidine-4-carboxylic acid;(R)-3-((S)-5-Oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid;(R)-3-[(S)-(5-Oxo-2-pyrrolidinyl) carbonyl]-thiazolidine-4-carboxylic acid;3-L-Pyroglutamyl-L-thiaziolidine-4carboxylic acid;PGT/1A

CAS NO.：121808-62-6
Empirical Formula: C9H12N2O4S
Molecular Weight: 244.27
MDL number: MFCD00867583
EINECS: 2017-001-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-06-18 13:53:09

What is Pidotimod?

Description

Pidotimod, a dipeptide immunomodulating agent, has been introduced as immunostimulant therapy in patients with cell-mediated immunosuppression during respiratory or urinary tract infections. Its mode of action on the immune system is by activation of T-lymphocytes via interleukin (IL)-2 stimulation and macrophages via activation of superoxide dismutase and chemotaxis. In mice, treatment with pidotimod causes significant increase in the natural killer cell activity that may play an important role in immunosurveillance against tumors and in physiological homeostasis. Pidotimod can reverse the immunosuppression caused by surgical stress and has antiinflammatory, antioxidant, and antiaging properties. It has also been reported to provide protection from bacterial infections in mice.

Chemical properties

White Solid

Originator

Poli (Italy)

The Uses of Pidotimod

Immunostimulant used in patients with cell-mediated immunodepression.

The Uses of Pidotimod

immune stimulant

What are the applications of Application

Pidotimod is a synthetic dipeptide with immunological modulatory activity on both the adaptive and innate immune responses

Definition

ChEBI: (4R)-3-[oxo-[(2S)-5-oxo-2-pyrrolidinyl]methyl]-4-thiazolidinecarboxylic acid is a peptide.

brand name

Polimod; Pigitil; Axil; Onaka

Properties of Pidotimod

Melting point:	194-198°C (dec.)
Boiling point:	663.0±55.0 °C(Predicted)
alpha	D25 -150° (c = 2 in 5N HCl)
Density	1.53
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO (Slightly, Heated), Methanol (Slightly, Heated), 5N HCl (Slightly)
form	powder
pka	3.03(at 25℃)
color	white to beige
optical activity	[α]/D -135 to -155°, c = 1 in 6 M HCl
Merck	14,7419
InChI	InChI=1S/C9H12N2O4S/c12-7-2-1-5(10-7)8(13)11-4-16-3-6(11)9(14)15/h5-6H,1-4H2,(H,10,12)(H,14,15)/t5-,6-/m0/s1
CAS DataBase Reference	121808-62-6(CAS DataBase Reference)

Safety information for Pidotimod

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.