Phenyllithium
Synonym(s):PhLi
- CAS NO.:591-51-5
- Empirical Formula: C6H5Li
- Molecular Weight: 84.05
- MDL number: MFCD00014254
- EINECS: 209-720-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-22 14:21:17
What is Phenyllithium?
Chemical properties
Phenyllithium is a colorless crystalline solid or dark brown to black solution, It is soluble in polar solvents such as ethers and tertiary amines but insoluble in hydrocarbons. Concentrated solutions in volatile solvents are pyrophoric but can be safely handled under inert atmosphere.
The Uses of Phenyllithium
Phenyllithium Solution (1.9M in Dibutyl Ether) is used as catalyst in the synthesis of pharmaceuticals. Used in the preparation of sulfonamides as well as in the preparation of orally bioavailable inhibitors of lipoprotein-associated phospholipase A2.
Preparation
Phenyllithium is usually prepared in the laboratory from bromobenzene and lithium metal in diethyl ether. Since phenyllithium cleaves ether, the solution must be used within a day or refrigerated. Industrially, it is produced from chlorobenzene and lithium metal dispersion in a benzene-ether mixture. A potentially useful and inexpensive process is one in which benzene is metalated by n-butyllithium in the presence of di-tertiary amines.
Definition
ChEBI: Phenyllithium is an aryllithium compound.
Properties of Phenyllithium
Melting point: | 160-163 °C(Solv: benzene (71-43-2)) |
Boiling point: | 140-143 °C |
Density | 0.835 g/mL at 25 °C |
Flash point: | 20 °C |
storage temp. | Store at +2°C to +8°C. |
solubility | Miscible with ether and hydrocarbons. |
form | Dark Brown Solution |
Water Solubility | Severe reaction |
Sensitive | Air & Moisture Sensitive |
BRN | 506502 |
Stability: | Moisture Sensitive |
CAS DataBase Reference | 591-51-5(CAS DataBase Reference) |
EPA Substance Registry System | Lithium, phenyl- (591-51-5) |
Safety information for Phenyllithium
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H226:Flammable liquids H314:Skin corrosion/irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
Computed Descriptors for Phenyllithium
InChIKey | NHKJPPKXDNZFBJ-UHFFFAOYSA-N |
Abamectin manufacturer
JSK Chemicals
Ortin Laboratories Limited
Organo Metallics
HYCHEM LABORATORIES
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