Phenyl trifluoromethanesulfonate
Synonym(s):Phenyl triflate
- CAS NO.:17763-67-6
- Empirical Formula: C7H5F3O3S
- Molecular Weight: 226.17
- MDL number: MFCD00192399
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:37
What is Phenyl trifluoromethanesulfonate?
Chemical properties
Colorless Liquid.
The Uses of Phenyl trifluoromethanesulfonate
Phenyl trifluoromethanesulfonate (phenyl triflate) may be used in the following studies:
As an arylating agent for the asymmetric α-arylation of ketones catalyzed by Pd(dba)2 and difluorphos.
As a reactant in the one pot synthesis of carbazoles by palladium-catalyzed N-arylation of anilines with phenyl triflate followed by oxidative coupling.
Synthesis of N-(2,6-diarylbenzoyl)anilines by diarylation of benzanilides with phenyl triflate in the presence of palladium-based catalyst.
As an arylating agent in the synthesis of (R)-2-phenyl-2,3-dihydrofuran by the arylation of 2,3-dihydrofuran.
Preparation
Synthesis of Phenyl trifluoromethanesulfonate: The reaction of phenol (1.00 g, 10.6 mmol) with triflic anhydride as outlined in the general procedure provided phenyl trifluoromethanesulfonate as colorless oil (0.73 g, 30%).
1H NMR (400 MHz, CDCl3) δ 7.50 – 7.42 (m, 2H), 7.41 – 7.36 (m, 1H), 7.32 – 7.24 (m, 2H).
General Description
Phenyl trifluoromethanesulfonate (phenyl triflate) is an aryl fluorosulphonate. It has been synthesized by the reaction of phenol with fluorosulphonic anhydride.
Properties of Phenyl trifluoromethanesulfonate
Boiling point: | 99-100 °C/60 mmHg (lit.) |
Density | 1.396 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | 160 °F |
storage temp. | Inert atmosphere,Room Temperature |
form | clear liquid |
color | Colorless to Almost colorless |
Safety information for Phenyl trifluoromethanesulfonate
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Phenyl trifluoromethanesulfonate
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