Phenactropinium chloride
- CAS NO.:3784-89-2
- Empirical Formula: C24H28ClNO4
- Molecular Weight: 0
- MDL number: MFCD00865797
- SAFETY DATA SHEET (SDS)
- Update Date: 2022-12-21 16:56:50
What is Phenactropinium chloride?
Originator
Trophenium ,American Cyanamid (AHP), US ,1961
Manufacturing Process
330 g (1.2 M) of homatropine were dissolved in 1 liter of dry methyl ethyl ketone and gently refluxed on a water-bath during the gradual addition of a solution of 204 g (1.32 M) redistilled phenacyl chloride in 200 ml of the same solvent. After 10 to 15 minutes 1 g of previously prepared homatropine phenacyl chloride was added to avoid formation of a supersaturated solution of the quaternary compound. Reflux was continued for 9 hours, then the thick suspension was allowed to cool, filtered and washed with 200 ml methyl ethyl ketone to yield 490 g (95%) slightly creamy solid, MP 188°C to 191°C.
For purification the crude quaternary salt was dissolved in hot ethyl alcohol (2 ml/g) and warm dry acetone (8 ml/g) was stirred into the clear filtrate. On cooling, 387 g (78 % recovery) of a pure white powder, MP 195°C to 197°C, were obtained, in which the ionizable chlorine assayed at 99.7% of the theoretical value.
Therapeutic Function
Antihypertensive
Properties of Phenactropinium chloride
Melting point: | 195-197° |
Safety information for Phenactropinium chloride
Computed Descriptors for Phenactropinium chloride
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