PF04191834
- CAS NO.：1029317-21-2
- Empirical Formula: C22H23N3O2S
- Molecular Weight: 393.5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 15:53:33
What is PF04191834?
Biological Activity
PF-4191834 (PF-04191834) is an orally active, non-iron-chelating, non-redox 5-lipoxygenase (5-LOX) inhibitor (IC50=229 nM), 5-LOX is about 300 times more selective than 12-LOX and 15-LOX, has no activity against cyclooxygenase, and is effective against inflammation and pain.
in vitro
PF-4191834 (PF-04191834) inhibits the synthesis of the 5-LOX products 5-HETE, 5-oxo-ETE, LTB4, and LTE4 with estimated IC 50 values between 100 and 190 nM and do not inhibit significantly the COX-1/2 enzymes or the 12- or 15-LOX enzymes at concentrations up to 30 μM. PF-4191834 (PF-04191834) exerts a concentration-dependent inhibition of human 5-LOX, with an IC 50 value of 130 nM and an IC 80 value of 370 nM.
Properties of PF04191834
| Melting point: | 173 °C |
| Boiling point: | 663.0±55.0 °C(Predicted) |
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 15.78±0.20(Predicted) |
| color | White to yellow |
Safety information for PF04191834
Computed Descriptors for PF04191834
New Products
4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 5-Bromo-2-nitropyridine 4-Methylphenylacetic acid (S)-3-Aminobutanenitrile hydrochloride 4-Fluorophenylacetic acid 3-chlorothieno[3,2-b]thiophene-2-carbaldehyde 2-(methyl amino)naphthalene-1-ol 2,4-dimethyl-6-(methylamine)phenol diethyl pyridine-2,6-dicarboxylate Methyl 5-methyloxazole-2-carboxylate 4-(4-(4-(trifluoromethoxy) phenoxy)piperidin-1-yl)phenol Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Aceclofenac IP/BP/EP Nimesulide BP Diclofenac Potassium Ethyl carbamate 2-Amino-5-nitropyridine Formalin; Methanal Benzyl carbamate 2,5-DiaminopyridineRelated products of tetrahydrofuran
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