PF-5190457

Synonym(s):1-[2-[(1R)-2,3-Dihydro-5-(6-methyl-4-pyrimidinyl)-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-ethanone;2-(2-Methylimidazo[2,1-b][1,3]thiazol-6-yl)-1-{2-[(1R)-5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2,7-diazaspiro[3.5]non-7-ylethanone;PF 5190457;PF-5190457

CAS NO.：1334782-79-4
Empirical Formula: C29H32N6OS
Molecular Weight: 512.67
Update Date: 2024-11-19 23:02:33

What is PF-5190457?

The Uses of PF-5190457

PF 5190457 is a potent, selective, and orally bioavailable ghrelin receptor inverse agonist.

Biochem/physiol Actions

PF-05190457 is an orally available, potent and selective ghrelin receptor inverse agonist. PF-05190457 potently increases insulin secretion in glucose-stimulated human islets.

storage

Store at -20°C

Properties of PF-5190457

Density	1.41±0.1 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: 250 mg/mL (487.64 mM)
pka	8.38±0.20(Predicted)
form	powder
color	white to beige
optical activity	[α]/D +45 to +55°, c = 0.5 in methanol

Safety information for PF-5190457

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.