PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE
Synonym(s):Diphenylphosphinic acid pentafluorophenyl ester;FDPP
- CAS NO.:138687-69-1
- Empirical Formula: C18H10F5O2P
- Molecular Weight: 384.24
- MDL number: MFCD00192380
- EINECS: 1308068-626-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-02-28 17:22:30
What is PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE?
Chemical properties
White to yellow solid
The Uses of PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE
Pentafluorophenyl Diphenylphosphinate is a reagent used as carboxyl activating group and a coupling agent in variety of amide bond formations.
The Uses of PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE
FDPP can be used as a coupling reagent in the:
- Synthesis of peptides by solid-phase and solution-phase reactions.
- Preparation of macrocyclic peptide cyclotheonamide B as a thrombin inhibitor.
- Cyclooligomerization of N-methylated-L-valine thiazole amino acid to obtain its cyclic tetramers.
- Macrocyclization of an intermediate for the total synthesis of ziziphine N , and for the macrolactamization of precursor in synthesizing cryptophycin D.
What are the applications of Application
Pentafluorophenyl diphenylphosphinate is Catalyst involved in coupling and macrocyclization
General Description
Pentafluorophenyl diphenylphosphinate (FDPP) is a reagent, used as a coupling agent in the amide bond forming reactions without racemization. It can also be employed in the synthesis of dipeptides with high yields and good optical purity. FDPP can be prepared from diphenylphosphinic chloride and pentafluorophenol in the presence of imidazole.
Properties of PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE
Melting point: | 47-50 °C (lit.) |
Boiling point: | 413.1±55.0 °C(Predicted) |
Density | 1.45 |
storage temp. | Sealed in dry,Room Temperature |
Safety information for PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
Computed Descriptors for PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE
InChIKey | OOWSDKUFKGVADH-UHFFFAOYSA-N |
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