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HomeProduct name listPENTAFLUOROPHENYL DIPHENYLPHOSPHINATE

PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE

Synonym(s):Diphenylphosphinic acid pentafluorophenyl ester;FDPP

  • CAS NO.:138687-69-1
  • Empirical Formula: C18H10F5O2P
  • Molecular Weight: 384.24
  • MDL number: MFCD00192380
  • EINECS: 1308068-626-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-02-28 17:22:30
PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE Structural

What is PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE?

Chemical properties

White to yellow solid

The Uses of PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE

Pentafluorophenyl Diphenylphosphinate is a reagent used as carboxyl activating group and a coupling agent in variety of amide bond formations.

The Uses of PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE

FDPP can be used as a coupling reagent in the:

  • Synthesis of peptides by solid-phase and solution-phase reactions.
  • Preparation of macrocyclic peptide cyclotheonamide B as a thrombin inhibitor.
  • Cyclooligomerization of N-methylated-L-valine thiazole amino acid to obtain its cyclic tetramers.
  • Macrocyclization of an intermediate for the total synthesis of ziziphine N , and for the macrolactamization of precursor in synthesizing cryptophycin D.

What are the applications of Application

Pentafluorophenyl diphenylphosphinate is Catalyst involved in coupling and macrocyclization

General Description

Pentafluorophenyl diphenylphosphinate (FDPP) is a reagent, used as a coupling agent in the amide bond forming reactions without racemization. It can also be employed in the synthesis of dipeptides with high yields and good optical purity. FDPP can be prepared from diphenylphosphinic chloride and pentafluorophenol in the presence of imidazole.

Properties of PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE

Melting point: 47-50 °C (lit.)
Boiling point: 413.1±55.0 °C(Predicted)
Density  1.45
storage temp.  Sealed in dry,Room Temperature

Safety information for PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

Computed Descriptors for PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE

InChIKey OOWSDKUFKGVADH-UHFFFAOYSA-N

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