(PENTAFLUOROETHYL)TRIMETHYLSILANE
Synonym(s):(Pentafluoroethyl)trimethylsilane
- CAS NO.：124898-13-1
- Empirical Formula: C5H9F5Si
- Molecular Weight: 192.2
- MDL number: MFCD04116436
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:32
What is (PENTAFLUOROETHYL)TRIMETHYLSILANE?
The Uses of (PENTAFLUOROETHYL)TRIMETHYLSILANE
(Pentafluoroethyl)trimethylsilane acts as a silicon-based fluorinating reagent for trifluoromethylation of carbonyls and ethylene diamines. It is also employed as a precursor for metal-mediated trifluoromethylation of aromatic, heteroaromatic and vinyl substrates.
The Uses of (PENTAFLUOROETHYL)TRIMETHYLSILANE
Silicon-based fluorinating reagents for the efficient trifluoromethylation of carbonyls and ethylene diamines. Precursors used for metal-mediated trifluoromethylation of aromatic, heteroaromatic, vinyl substrates, etc.
The Uses of (PENTAFLUOROETHYL)TRIMETHYLSILANE
Trimethylpentafluoroethylsilane ((Pentafluoroethyl)trimethylsilane) may be used as a perfluoroalkylating reagent for the synthesis of the following quinoline derivatives:
- 5-bromo-2-(perfluoroethyl)quinoline
- 8-methoxy-2-(perfluoroethyl)quinoline
- 1-(perfluoroethyl)isoquinoline
- 8-(tert-butoxy)-5,7-dichloro-2-(perfluoroethyl)quinolone
General Description
Trimethylpentafluoroethylsilane ((Pentafluoroethyl)trimethylsilane) is a perfluoroalkylsilane. Alkyl triflates undergo nucleophilic pentafluoroethylation with trimethylpentafluoroethylsilane to form the corresponding pentafluoroethylated alkanes.
Properties of (PENTAFLUOROETHYL)TRIMETHYLSILANE
| Boiling point: | 60 °C |
| Density | 1.095 g/mL |
| refractive index | 1.3270 |
| Flash point: | -17℃ |
| solubility | Miscible with tetrahydrofuran. |
| form | liquid |
| color | colorless |
| Specific Gravity | 1.05 |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| Sensitive | Moisture Sensitive |
| Stability: | Moisture Sensitive, Volatile |
| CAS DataBase Reference | 124898-13-1(CAS DataBase Reference) |
| EPA Substance Registry System | (Pentafluoroethyl)trimethylsilane (124898-13-1) |
Safety information for (PENTAFLUOROETHYL)TRIMETHYLSILANE
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (PENTAFLUOROETHYL)TRIMETHYLSILANE
New Products
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