paraherquamide
- CAS NO.:77392-58-6
- Empirical Formula: C28H35N3O5
- Molecular Weight: 493.59
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is paraherquamide?
Description
Paraherquamide A is a mycotoxin anthelmintic originally isolated from P. paraherquei. It binds to acetylcholine receptors (IC50 = 0.5 nM for head homogenates of M. domestica) and acts as an antagonist. Paraherquamide A is toxic to C. elegans (LD50 = 2.5 μg/ml) and effective against T. colubriformis infection in gerbils when used at doses ranging from 0.39 to 200 mg/kg. It is toxic to mice (LD50 = 14.9 mg/kg).
The Uses of paraherquamide
Paraherquamide A was first reported as a mycotoxin related to the indole tremorgenic mycotoxins. Subsequent research identified a potent, non-toxic paralysis of nematodes which led to the metabolite's development as a candidate anthelmintic. Paraherquamide A is a selective, competitive, cholinergic antagonist that distinguishes subtypes of cholinergic receptors.
The Uses of paraherquamide
Paraherquamide A is a selective, competitive, cholinergic antagonist.
What are the applications of Application
Paraherquamide A is a selective, competitive, cholinergic antagonist
Properties of paraherquamide
Melting point: | 244-247° (dec) |
alpha | D22 -28° (c = 0.43 in methanol) |
storage temp. | Store at -20°C |
solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble |
form | White to off-white powder. |
Safety information for paraherquamide
Computed Descriptors for paraherquamide
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