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paraherquamide

paraherquamide Structural

What is paraherquamide?

Description

Paraherquamide A is a mycotoxin anthelmintic originally isolated from P. paraherquei. It binds to acetylcholine receptors (IC50 = 0.5 nM for head homogenates of M. domestica) and acts as an antagonist. Paraherquamide A is toxic to C. elegans (LD50 = 2.5 μg/ml) and effective against T. colubriformis infection in gerbils when used at doses ranging from 0.39 to 200 mg/kg. It is toxic to mice (LD50 = 14.9 mg/kg).

The Uses of paraherquamide

Paraherquamide A was first reported as a mycotoxin related to the indole tremorgenic mycotoxins. Subsequent research identified a potent, non-toxic paralysis of nematodes which led to the metabolite's development as a candidate anthelmintic. Paraherquamide A is a selective, competitive, cholinergic antagonist that distinguishes subtypes of cholinergic receptors.

The Uses of paraherquamide

Paraherquamide A is a selective, competitive, cholinergic antagonist.

What are the applications of Application

Paraherquamide A is a selective, competitive, cholinergic antagonist

Properties of paraherquamide

Melting point: 244-247° (dec)
alpha  D22 -28° (c = 0.43 in methanol)
storage temp.  Store at -20°C
solubility  DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form  White to off-white powder.

Safety information for paraherquamide

Computed Descriptors for paraherquamide

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