Palonosetron
- CAS NO.:149653-99-6
- Empirical Formula: C19H24N2O
- Molecular Weight: 296.41
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-03-13 11:54:02
What is Palonosetron?
Indications
Palonosetron is approved by the US FDA for acute and delayed CINV and PONV.
Biological Activity
Palonosetron is a highly selective, high-affinity 5-HT3 receptor antagonist. Due to its structural difference from the first-generation 5-HT3 receptor antagonists, palonosetron has an affinity for the 5-HT3 receptor at least 30 times that of other similar drugs.
in vitro
Palonosetron is neither an inhibitor of CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1 and CYP3A4/5 (CYP2C19 not studied) nor does it induce the activity of CYP1A2, CYP2D6 or CYP3A4/5.
Properties of Palonosetron
Boiling point: | 470.4±45.0 °C(Predicted) |
Density | 1.24 |
pka | 9.77±0.33(Predicted) |
Safety information for Palonosetron
Computed Descriptors for Palonosetron
New Products
Bromine 99.5% AR (4 x 500ml) Fehling's Solution No. B Amino Acid Kit of 23 items set Ammonium Molybdate Reagent Solution Beam's Reagent Solution Ehrlich's Reagent For detection of urobillinogen Sodium Amino Salicylate Dihydrate (PAS Sodium) IP/BP/USP/EP 1,2,3,4-Tetrahydrocarbazol-4-one 4-Hydroxy Carbazole Amino Salicylic Acid. U.S.P. 2 – Methoxy – 5- Sulfamoyl Benzoic acid Acetone Isobutryl oxime ester Curcuma aromatica Oil Curry leaf Extract Terminalia bellirica Extract Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract Ethyl 3-(Pyridin-2-Ylamino)Propanoate Bilastine -IP/BP/ Cypermethric Acid Chloride 5-Nitrosalicylaldehyde 5-(Difluoromethoxy)-2-Mercapto-1H-Benzimidazole- IP/BP/ Methyl Di Chloride (Mdc)Related products of tetrahydrofuran
1H-Benz[de]isoquinolin-1-one,2,4,5,6-tetrahydro-2-[(3S)-1-oxido-1-azabicyclo[2.2.2]oct-3-yl]-
Palonosetron Impurity 12
Palonosetron Impurity 7
Palonosetron Impurity 11
(R,S)-Palonosetron Hydrochloride
(S,R)-Palonosetron Hydrochloride
Palonosetron impurity
6-Hydroxy Palonosetron
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