Palonosetron
- CAS NO.:149653-99-6
- Empirical Formula: C19H24N2O
- Molecular Weight: 296.41
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-03-13 11:54:02
What is Palonosetron?
Indications
Palonosetron is approved by the US FDA for acute and delayed CINV and PONV.
Biological Activity
Palonosetron is a highly selective, high-affinity 5-HT3 receptor antagonist. Due to its structural difference from the first-generation 5-HT3 receptor antagonists, palonosetron has an affinity for the 5-HT3 receptor at least 30 times that of other similar drugs.
in vitro
Palonosetron is neither an inhibitor of CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1 and CYP3A4/5 (CYP2C19 not studied) nor does it induce the activity of CYP1A2, CYP2D6 or CYP3A4/5.
Properties of Palonosetron
Boiling point: | 470.4±45.0 °C(Predicted) |
Density | 1.24 |
pka | 9.77±0.33(Predicted) |
Safety information for Palonosetron
Computed Descriptors for Palonosetron
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
1H-Benz[de]isoquinolin-1-one,2,4,5,6-tetrahydro-2-[(3S)-1-oxido-1-azabicyclo[2.2.2]oct-3-yl]-
Palonosetron Impurity 12
Palonosetron Impurity 7
Palonosetron Impurity 11
(R,S)-Palonosetron Hydrochloride
(S,R)-Palonosetron Hydrochloride
Palonosetron impurity
6-Hydroxy Palonosetron
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