Palonosetron
- CAS NO.：149653-99-6
- Empirical Formula: C19H24N2O
- Molecular Weight: 296.41
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-03-13 11:54:02
What is Palonosetron?
Indications
Palonosetron is approved by the US FDA for acute and delayed CINV and PONV.
Biological Activity
Palonosetron is a highly selective, high-affinity 5-HT3 receptor antagonist. Due to its structural difference from the first-generation 5-HT3 receptor antagonists, palonosetron has an affinity for the 5-HT3 receptor at least 30 times that of other similar drugs.
in vitro
Palonosetron is neither an inhibitor of CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1 and CYP3A4/5 (CYP2C19 not studied) nor does it induce the activity of CYP1A2, CYP2D6 or CYP3A4/5.
Properties of Palonosetron
| Boiling point: | 470.4±45.0 °C(Predicted) |
| Density | 1.24 |
| pka | 9.77±0.33(Predicted) |
Safety information for Palonosetron
Computed Descriptors for Palonosetron
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