Paliperidone Palmitate
- CAS NO.:199739-10-1
- Empirical Formula: C39H57FN4O4
- Molecular Weight: 664.89
- MDL number: MFCD24386477
- EINECS: 225-799-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-06 15:28:16
What is Paliperidone Palmitate?
Description
Paliperidone palmitate is an atypical long acting antipsychotics,which can fast onset in acute phase and continuously improve the symptoms in maintenance phase. It has the solid efficacy and convenient ad[1]ministration,which offer a new option for schizophrenia treatment and will help patients to adhere the treatment and prevent relapse. As the sole long acting antipsychotics with monthly injection,it was approved by CFDA in 2011 and indicated for the acute and maintenance treatment of schizophrenia.
The Uses of Paliperidone Palmitate
Paliperidone Palmitate is a long-acting injectable atypical antipsychotic used in the treatment of schizophrenia.
Definition
ChEBI: 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl hexadecanoate is a fatty acid ester obtained by the formal condensation of the carboxy group of hexadecanoic acid with the hydroxy group of 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one. It is a member of 1,2-benzoxazoles, a heteroarylpiperidine, an organofluorine compound, a pyridopyrimidine and a fatty acid ester.
Side Effects
The review of the literature also underlined that paliperidone palmitate is well tolerated, compared with placebo. Frequency and severity of side-effects such as extrapyramidal symptoms, hyperprolactinemia and weight gain, was similar or less than those found in treatment with other atypical antipsychotics, including long-acting ones.
Properties of Paliperidone Palmitate
Melting point: | 110-115°C |
Boiling point: | 736.3±70.0 °C(Predicted) |
Density | 1.19 |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly, Heated, Sonicated), Methanol (Sl |
form | Solid |
pka | 8.07±0.10(Predicted) |
color | Off-White to Light Beige |
Safety information for Paliperidone Palmitate
Computed Descriptors for Paliperidone Palmitate
Paliperidone Palmitate manufacturer
SVK Laboratories Pvt Ltd
Piramal Pharma Solutions
Rivashaa Agrotech Biopharma Pvt. Ltd.
Ralington Pharma
Flowchem Pharma Pvt Ltd
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