P-Toluenesulfonic anhydride
- CAS NO.:4124-41-8
- Empirical Formula: C14H14O5S2
- Molecular Weight: 326.38
- MDL number: MFCD00008548
- EINECS: 223-926-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-18 08:51:57
What is P-Toluenesulfonic anhydride?
Chemical properties
Off-white to cream powder
The Uses of P-Toluenesulfonic anhydride
p-Toluenesulfonic anhydride has been employed as reagent in palladium-catalyzed allylic alkenylation of allylic alcohols with n-butyl acrylate.
General Description
p-Toluenesulfonic anhydride acts as electrophilic species and activates 2-deoxy-sugar hemiacetals in situ, which reacts stereoselectively with nucleophilic acceptors to afford β-anomers.
Synthesis
Add p-toluenesulfonic acid and an m-phosphorous compound used as raw materials into a reaction kettle, dropwise adding thionyl chloride while stirring. Controlling the temperature in the reaction kettle at 68-76 ℃ and heating to perform condensation after dropwise addition; inputting water and hydrochloric acid into the reaction kettle, cooling to 0 ℃. The reaction solution generated in the previous step was drawn into the water, vacuum filtration was performed, and centrifuging was used to obtain a crude product, p-toluenesulfonic anhydride. Furthermore, it was inputting ethyl acetate, performing heating reflux, and freezing to perform crystallization, thus obtaining the qualified finished product.
Properties of P-Toluenesulfonic anhydride
Melting point: | 121-127 °C(lit.) |
Boiling point: | 478.0±48.0 °C(Predicted) |
Density | 1.361±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,2-8°C |
form | Powder, Crystals and/or Chunks |
color | Off-white to gray |
Sensitive | Moisture Sensitive |
BRN | 2223702 |
CAS DataBase Reference | 4124-41-8(CAS DataBase Reference) |
Safety information for P-Toluenesulfonic anhydride
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for P-Toluenesulfonic anhydride
InChIKey | PDVFSPNIEOYOQL-UHFFFAOYSA-N |
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